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Differential regulation of multidrug resistance gene(s) in the clinical isolates of pathogenic yeast Candida albicans

Shodhganga@INFLIBNET

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Title Differential regulation of multidrug resistance gene(s) in the clinical isolates of pathogenic yeast Candida albicans
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Contributor Prasad, Rajendra
 
Subject Life Science
Candida albicans
multidrug resistance gene(s)
pathogenic yeast
 
Description Toxic compounds such as drugs are used to treat many diseases by killing the harmful target cells, which can be either foreign pathogenic organisms or the tumor cells of the patients.
newlineHowever, both prokaryotic and eukaryotic cells can acquire the ability to become resistant to
newlinetoxic compounds through the phenomenon of Multidrug (MDR) or Pleiotropic drug resistance
newline(PDR). MDR is characterized by the cross-resistance of cells to a large number of structurally
newlineand functionally unrelated cytotoxic compounds. The pathogenic yeast, Candida albicans can
newlinealso acquire MDR, making it a valuable tool in the study of this phenomenon so that we may
newlinegain insights into the mechanisms behind MDR in pathogenic fungi and in higher eukaryotes.
newlineA common feature underlying acquisition of MDR in azole resistant clinical C. albicans
newlineisolate is the over-expression of genes encoding plasma membrane A TP-binding cassette
newline(ABC) drug efflux pump, CDR1 (Candida drug resistance 1) that causes :he expulsion of
newlinedrugs from within the cell and, as a result, survival in the presence of these drugs.
newlineResearch to overcome this problem in candidiasis chemotherapy has been focused mainly on
newlinetwo areas: (1) development of Cdrl p modulators/inhibitors, (2) advanced and sensitive
newlinedetection of CDR1 mRNA or Cdrlp and its expression regubtion. However, recent
newlineunderstanding of the transcriptional regulation of efflux pump CDR 1 , provides new and
newlineeffective avenues for the development of broad-spectrum fungicides in contrast to indirect
newlineintervention via inhibition of the energy supply for drug efflux by modulators/inhibitors.
newlineThe main focus of this study was, however, in processes different from the classical
newlinetranscriptional control as majority of studies to date focus on the transcriptional regulation of CDR1 and relevance of the post-transcriptional events associated with it are poorly understood.
Bibliography p.108-136
 
Date 2014-01-06T08:44:18Z
2014-01-06T08:44:18Z
2014-01-06
n.d.
2008
n.d.
 
Type Ph.D.
 
Identifier http://hdl.handle.net/10603/14657
 
Language English
 
Relation -
 
Rights university
 
Format 136p.
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None
 
Coverage Life Sciences
 
Publisher Delhi
Jawaharlal Nehru University
School of Life Sciences
 
Source INFLIBNET