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Effect of curcumin and eugenol on iron-induced in rats hepatic toxicity

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Relation http://ir.cftri.com/1496/
T_02_96
 
Title Effect of curcumin and eugenol on iron-induced
in rats hepatic toxicity
 
Creator Pulla Reddy, A. C.
Lokesh, B. R.
 
Subject 30 Spices/Condiments
11 Lipid Biochemistry
17 Toxicology
 
Description Male Wistar rats injected i.p. with 30 mg Fe’+ikg body weight show hepatic damage as measured by an increase
in lipid peroxides which correlated with elevated serum enzymes, alanine aminotransferase (ALAT), aspartate amino-
transferase (ASAT) and lactate dehydrogenase (LDH). Oral administration of spice principles, curcumin from turmeric
(30 mgkg body weight) or eugenol from cloves (100 mgkg body weight), for 10 days lowered the liver and serum lipid
peroxide levels, serum ALAT, ASAT and LDH, enhanced by i.p. injection of iron. This study indicates that curcumin
or eugenol reduces the iron-induced hepatic damage by lowering lipid peroxidation.
 
Date 1996
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
Rights —
 
Identifier http://ir.cftri.com/1496/1/Toxicology_107_%281996%29_39-45.pdf
Pulla Reddy, A. C. and Lokesh, B. R. (1996) Effect of curcumin and eugenol on iron-induced in rats hepatic toxicity. Toxicology, 107. pp. 39-45.