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Toxicological assessment of the yeast Rhodotorula gracilis in experimental animals

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Relation http://ir.cftri.com/1507/
Z_05_99
 
Title Toxicological assessment of the yeast Rhodotorula gracilis in experimental animals
 
Creator Akhilender Naidu, K.
Venkateswaran, G.
Vijayalakshmi, G.
Manjula, K.
 
Subject 19 Yeast
17 Toxicology
 
Description Rhodotorula gracilis is an oleaginous yeast
known to synthesize lipids and carotenoid pigments. In
this study, the toxicological evaluation of a locally isolated strain, R. gracilis CFR-1, in freeze-dried form has been studied to assess its safety as a source of natural colorant and nutritional additive in experimental animals. Acute and subacute studies on freeze-dried R.
gracilis were conducted on both sexes of albino rats.
Acute doses of R. gracilis at 0.5–6.0 g/kg body weight
(w/w) did not show any symptoms of toxicity nor mortality
of the adult rats. Feeding of low concentrations of
R. gracilis at the 0.1–2.0% level (w/w) for 14 weeks did
not induce any significant change in food intake and
gain in body weight of the experimental rats compared
to control animals. There were no significant differences
in the absolute and relative weights of vital organs,
hematological parameters, macroscopic and microscopic
changes in vital organs and serum enzyme
levels between the experimental and control groups.
The fecal matter of R. gracilis-fed rats did not show any
viable cells. The results clearly show that acute and subacute oral feeding of freeze-dried whole cells of R. gracilis for 14 weeks did not produce any toxic effects on
male and female rats.
 
Date 1999
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
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Identifier http://ir.cftri.com/1507/1/Zeitschrift_f%C3%BCr_Lebensmitteluntersuchung_und_-Forschung_A_208%281999%29444-448.pdf
Akhilender Naidu, K. and Venkateswaran, G. and Vijayalakshmi, G. and Manjula, K. (1999) Toxicological assessment of the yeast Rhodotorula gracilis in experimental animals. Zeitschrift für Lebensmitteluntersuchung und -Forschung A , 208. pp. 444-448.