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Partially saturated canthaxanthin purified from Aspergillus carbonarius induces apoptosis in prostrate cancer cell line.

IR@CSIR-CFTRI

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Relation http://ir.cftri.com/1779/
AMB-01-08
 
Title Partially saturated canthaxanthin purified from Aspergillus carbonarius induces apoptosis in prostrate cancer cell line.
 
Creator Kumaresan, N.
Sanjay, K. R.
Venkatesh, S. K.
Ravi Kumar, Kadeppagari
Vijayalakshmi, G.
Umesh Kumar, S.
 
Subject 04 Microbiology
 
Description A mutant Aspergillus carbonarius selected for temperature tolerance after UV treatment, when grown in shake flasks, produced mycelia bearing yellow pigment. Since the mutant was affected in sterol biosynthetic pathway, the pigment was apparently produced to maintain membrane fluidity and rigidity for growth sustenance in low-pH culture broth. Nuclear magnetic resonance analyses characterizing the pigment as a partially saturated canthaxanthin, containing beta-ionone end rings, suggested its application as a retinoid. When tested for this property in retinoic acid receptor expressing prostate cancer cell line, LNCaP, the fungal partially saturated canthaxanthin induced apoptosis. Low apoptosis percentage in DU145 prostrate cancer cells that does not express functional retinoic acid receptor-beta (RAR-beta) suggested binding specificity of the partially saturated canthaxanthin for RAR-beta.
 
Date 2008
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
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Identifier http://ir.cftri.com/1779/1/Appl_Microbiol_Biotechnol_%282008%29_80_467%E2%80%93473.pdf
Kumaresan, N. and Sanjay, K. R. and Venkatesh, S. K. and Ravi Kumar, Kadeppagari and Vijayalakshmi, G. and Umesh Kumar, S. (2008) Partially saturated canthaxanthin purified from Aspergillus carbonarius induces apoptosis in prostrate cancer cell line. Applied Microbiology and Biotechnology, 80. pp. 467-473. ISSN 0175-7598