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Characterization of dehydromonacolin-MV2 from Monascus purpureus mutant.

IR@CSIR-CFTRI

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Relation http://ir.cftri.com/1817/
JAM-03-07
 
Title Characterization of dehydromonacolin-MV2 from Monascus purpureus mutant.
 
Creator Dhale, M. A.
Divakar, S.
Umesh Kumar, S.
Vijayalakshmi, G.
 
Subject 04 Fungi
32 Antioxidants
 
Description AIM: Characterization of dehydromonacolin-MV2, a bioactive metabolite isolated from Monascus purpureus mutant (CFR 410-11). METHODS AND RESULTS: Chloroform extract of rice, fermented with a hyperpigment-producing mutant of M. purpureus (CFR 410-11) was found to contain metabolites that inhibited the growth of Bacillus, Pseudomonas and Streptococcus in agar gel diffusion assays. The extract inhibited lipid peroxidation and scavenged 2,2-diphenyl-1-pycrylhydrazyl and hydroxyl radicals. The active compound purified by silica gel column chromatography was characterized by NMR. The carbon, proton and 2D HSQCT assignments identified dehydromonacolin-MV2 as the bioactive metabolite. CONCLUSIONS: Dehydromonacolin-MV2 apparently originated in the mutant by hydroxylation and oxidation of monacolin-J, an intermediate of monacolin biosynthetic pathway. SIGNIFICANCE AND IMPACT OF THE STUDY: Identification of the production of dehydromonacolin-MV2 by M. purpureus mutant (CFR 410-11) is new to literature. Bioactive properties of the compound suggested its pharmaceutical applications.
 
Date 2007
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
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Identifier http://ir.cftri.com/1817/1/Journal_of_Applied_Microbiology_103%286%29_2007_2168-2173.pdf
Dhale, M. A. and Divakar, S. and Umesh Kumar, S. and Vijayalakshmi, G. (2007) Characterization of dehydromonacolin-MV2 from Monascus purpureus mutant. Journal of applied microbiology, 103 (6). pp. 2168-73. ISSN 1364-5072