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Hypolipidemic and antioxidant effects of curcumin and capsaicin in high-fat-fed rats.

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CJPP-02-07
 
Title Hypolipidemic and antioxidant effects of curcumin and capsaicin in high-fat-fed rats.
 
Creator Manjunatha, H.
Srinivasan, K.
 
Subject 30 Spices/Condiments
32 Antioxidants
 
Description The beneficial hypolipidemic and antioxidant influences of the dietary spice compounds curcumin and capsaicin were evaluated. Curcumin, capsaicin, or their combination were included in the diet of high-(30%)-fat-fed rats for 8 weeks. Dietary high-fat-induced hypertriglyceridemia was countered by dietary curcumin, capsaicin, or their combination by 12%-20%. Curcumin, capsaicin, and their combination also produced a slight decrease in serum total cholesterol in these animals. Serum alpha-tocopherol content was increased by dietary curcumin, capsaicin, and their combination in high-fat-fed rats. Serum total thiol content in high-fat-fed animals and serum ascorbic acid in normal animals was elevated by the combination of curcumin and capsaicin. Hepatic glutathione was increased by curcumin, capsaicin, or their combination in normal animals. Hepatic glutathione and alpha-tocopherol were increased, whereas lipid peroxide level was reduced by dietary curcumin and combination of curcumin and capsaicin in high-fat-fed animals. Serum glutathione peroxidase and glutathione transferase in high-fat-fed rats were generally higher as a result of dietary curcumin, capsaicin, and the combination of curcumin and capsaicin. Hepatic glutathione reductase and glutathione peroxidase were significantly elevated by dietary spice principles in high-fat-fed animals. The additive effect of the 2 bioactive compounds was generally not evident with respect to hypolipidemic or antioxidant potential. However, the effectiveness of the combination was higher in a few instances.
 
Date 2007
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
Identifier http://ir.cftri.com/1839/1/Can._J._Physiol._Pharmacol._85_588%E2%80%93596_%282007%29.pdf
Manjunatha, H. and Srinivasan, K. (2007) Hypolipidemic and antioxidant effects of curcumin and capsaicin in high-fat-fed rats. Canadian Journal of Physiology and Pharmacology, 85 (6). pp. 588-96. ISSN 0008-4212