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Glycosides and amino acyl esters of carbohydrates as potent inhibitors of angiotensin converting enzyme.

IR@CSIR-CFTRI

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Relation http://ir.cftri.com/1934/
EJMC-01-06
 
Title Glycosides and amino acyl esters of carbohydrates as potent inhibitors of angiotensin converting enzyme.
 
Creator Lohith, K.
Vijayakumar, G. R.
Somashekar, B. R.
Sivakumar, R.
Divakar, S.
 
Subject 01 Carbohydrates
 
Description About 12 glycosides prepared through amyloglucosidase catalysis and 23 amino acyl esters of carbohydrates prepared through lipase catalysis in organic solvents showed angiotensin converting enzyme (ACE) inhibition activity. Both amino acyl esters of carbohydrates and glycosides exhibited IC50 values for ACE inhibition in the 0.5 mM to 15.7 mM range. Eugenyl-D-glucoside (IC50: 0.5+/-0.04 mM), L-isoleucyl-D-glucose (IC50: 0.7+/-0.067 mM), vanillyl-D-sorbitol (IC50: 0.8+/-0.09 mM), L-histidyl-D-fructose (IC50: 0.9+/-0.087 mM), L-tryptophanyl-D-fructose (IC50: 0.9+/-0.092 mM), octyl-D-glucoside (IC50: 1.0+/-0.093 mM), vanillyl-D-mannoside (IC50: 1.0+/-0.089 mM), L-valyl-D-mannitol (IC50: 1.0+/-0.092 mM) and L-phenylalanyl-D-glucose (IC50: 1.0+/-0.089 mM) were the compounds, which showed the best ACE inhibitory activities.
 
Date 2006
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
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Identifier http://ir.cftri.com/1934/1/European_Journal_of_Medicinal_Chemistry_41%289%29_2006_1059-1072.pdf
Lohith, K. and Vijayakumar, G. R. and Somashekar, B. R. and Sivakumar, R. and Divakar, S. (2006) Glycosides and amino acyl esters of carbohydrates as potent inhibitors of angiotensin converting enzyme. European Journal of Medicinal Chemistry, 41 (9). pp. 1059-72. ISSN 0223-5234