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Swallow root (Decalepis hamiltonii) pectic oligosaccharide (SRO1) induces cancer cell death via modulation of galectin-3 and surviving.

IR@CSIR-CFTRI

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Relation http://ir.cftri.com/13551/
https://doi.org/10.1016/j.carbpol.2018.01.053
 
Title Swallow root (Decalepis hamiltonii) pectic oligosaccharide (SRO1) induces
cancer cell death via modulation of galectin-3 and surviving.
 
Creator Mallikarjuna, S. E.
Dharmesh, Shylaja M
 
Subject 28 Polysaccharide Chemistry
Swallow root
 
Description Swallow root pectic oligosaccharide fraction (SRO1) from swallow root pectic polysaccharide (SRPP) possessed a
molecular size of 831 Da. Structural analysis revealed that it is a rhamnogalacturonan I type, bearing arabinogalactan
side chain with β-D-(1→4) galactose along with α-L-Araf (1→5)-α-L-Araf (1→3) structure on α-D-GalAOAc-(
1→2)-α-L-Rha-(1→4)- linear backbone. β-D (1→4) linked galactose being the specific sugar for galectin-3,
SRO1 had potentials in inhibiting galectin-3 mediated cancer progression. SRO1 inhibited galectin-3 mediated
agglutination, in vitro, effectively with MIC of 1.08 μg/ mL and down regulated mRNA levels of galectin-3
(∼92%) along with its downstream key protein that inhibits apoptosis – survivin (∼78%) suggesting the capability
of SRO1 in inhibiting galectin-3 mediated cancer promoting pathway. This is the first report, which
highlights the inhibition of interplay of galectin-3 and survivin by a dietary pectic oligosaccharide.
 
Date 2018
 
Type Article
PeerReviewed
 
Format pdf
 
Language en
 
Identifier http://ir.cftri.com/13551/1/Carbohydrate%20Polymers%20186%20%282018%29%20402%E2%80%93410.pdf
Mallikarjuna, S. E. and Dharmesh, Shylaja M (2018) Swallow root (Decalepis hamiltonii) pectic oligosaccharide (SRO1) induces cancer cell death via modulation of galectin-3 and surviving. Carbohydrate Polymers, 186. pp. 402-410.