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Protective Effect of Probiotic Enterococcus faecium NCIM 5593 on Acrylamide Induced Neurotoxicity in Adult Mice.

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Relation http://ir.cftri.com/13811/
https://dx.doi.org/10.4172/2329-8901.1000165
 
Title Protective Effect of Probiotic Enterococcus faecium NCIM 5593 on
Acrylamide Induced Neurotoxicity in Adult Mice.
 
Creator Divyashri, G.
Prapulla, S. G.
 
Subject 02 Bacteriology
 
Description Exposure to chemicals that are commonly distributed in the environment and work-related surroundings may
have deleterious effects to the nervous system. Acrylamide (ACR) is a well-known neurotoxin with multiple chemical
and industrial applications. ACR exposure is attributed to oxidative stress and is known to cause neurotoxic effect by
altering brain neurotransmitter levels. Probiotics are chosen as natural therapeutic medicine against oxidative stress
and shown their ability to modulate gut-brain axis. Aim of the present study was to evaluate the beneficial effect of
probiotic Enterococcus faecium NCIM 5593 on ACR induced oxidative stress altered neurotransmitter status in mice
brain. ACR exposure to mice produced pronounced neurotoxicity as evidenced by marked increase in oxidative
markers and altered antioxidant ability. Probiotic treatment (4 weeks) to young mice could diminish ACR induced
elevation in oxidative markers in brain and enhance activities of antioxidant enzymes with increase in gammaaminobutyric
acid (GABA) and dopamine (DA) levels. Oral supplements of E. faecium NCIM 5593 to ACR-treated
mice improved neuronal dysfunction and oxidative stress. The present study suggests that this probiotic strain can
be a potential neutraceutical intervention to combat acrylamide induced molecular alterations and oxidative stress.
 
Date 2017
 
Type Article
PeerReviewed
 
Format pdf
 
Language en
 
Identifier http://ir.cftri.com/13811/1/J%20Prob%20Health%202017%2C%2051.pdf
Divyashri, G. and Prapulla, S. G. (2017) Protective Effect of Probiotic Enterococcus faecium NCIM 5593 on Acrylamide Induced Neurotoxicity in Adult Mice. Journal of Probiotics and Health, 5 (1). pp. 1-11.