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Fatty acids modulate the efficacy of lutein in cataract prevention: Assessment of oxidative and inflammatory parameters in rats.

IR@CSIR-CFTRI

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Relation http://ir.cftri.com/13848/
https://doi.org/10.1016/j.bbrc.2018.04.098
 
Title Fatty acids modulate the efficacy of lutein in cataract prevention:
Assessment of oxidative and inflammatory parameters in rats.
 
Creator Smitha, P.
Baskaran, V.
 
Subject 17 Fatty Acid Chemistry
 
Description Background

Effects of lutein (L) and fatty acids [linoleic acid (LA), eicosapentaenoic acid (EPA)+docosahexaenoic acid (DHA) and oleic acid (OA)] on oxidative stress and inflammation in cataract were assessed.
Methods

Cataract was induced in male Wistar rat pups (11 days old) by giving a single dose of sodium selenite (25 μM/kg body weight) by IP. Lutein (1.3 μmol/kg body weight) was given one day before and five days after selenite injection as a micelle with 7.5 mM LA, or 7.5 mM EPA + DHA or 7.5 mM OA. Serum and lens oxidative stress and inflammatory parameters having a bearing cataract were assessed.
Results

Serum and lens nitric oxide, MDA and protein carbonyls were significantly (p 
 
Date 2018
 
Type Article
PeerReviewed
 
Format pdf
 
Language en
 
Identifier http://ir.cftri.com/13848/1/Biochemical%20and%20Biophysical%20Research%20Communications%20xxx%20%282018%29%201e8.pdf
Smitha, P. and Baskaran, V. (2018) Fatty acids modulate the efficacy of lutein in cataract prevention: Assessment of oxidative and inflammatory parameters in rats. Biochemical and Biophysical Research Communications, 500 (2). pp. 435-442. ISSN 0006-291X