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Ameliorative influence of dietary fenugreek (Trigonella foenumgraecum) seeds and onion (Allium cepa) on eye lens abnormalities via modulation of crystallin proteins and polyol pathway in experimental diabetes.

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Relation http://ir.cftri.com/13862/
https://dx.doi.org/10.1080/02713683.2018.1484146
 
Title Ameliorative influence of dietary fenugreek (Trigonella foenumgraecum)
seeds and onion (Allium cepa) on eye lens abnormalities
via modulation of crystallin proteins and polyol pathway in
experimental diabetes.
 
Creator Pradeep, S. R.
Srinivasan, K.
 
Subject 04 Diabetes Mellitus
08 Fenugreek
 
Description Purpose and Methods: Hyperglycemia induced osmotic and oxidative stress is thought to be
involved in the pathogenesis of diabetes related secondary complications including cataract. In
continuation of our previous observation of the ameliorative influence of these spices on
hyperglycemia, attendant metabolic abnormalities, and oxidative stress in tissues of diabetic rats,
the beneficial influence of dietary (10%) fenugreek seeds, (3%) onion or their combination was
investigated on diabetes induced alteration in the eye lens of STZ-induced diabetic rats.
Results: Animals maintained on these spices showed significantly countered oxidative stress
markers (ROS, lipid peroxidation and protein carbonyl), AGEs and expression of their receptor
(RAGE) in the eye lens. Increased activity of polyol pathway enzymes, their protein and mRNA
expression was significantly countered in the cataractogenic lens as a result of these dietary
interventions. Altered crystallin (αA and αB) distribution profile, their expression, activity of
Accepted Manuscript
2
carbohydrate metabolizing enzymes and antioxidant status were significantly annulled by these
dietary treatments. Physical and visual observation of the photomicrographs of the lenses of
treated rats indicated that these dietary interventions delayed cataractogenesis in diabetic rats.
Conclusions: Overall, the present investigation evidenced a beneficial modulation of the
progression of cataractogenesis by dietary fenugreek seeds and onion, implicating their potential
in ameliorating cataract in diabetics.
 
Date 2018
 
Type Article
PeerReviewed
 
Format pdf
 
Language en
 
Identifier http://ir.cftri.com/13862/1/Current%20Eye%20research%202018.pdf
Pradeep, S. R. and Srinivasan, K. (2018) Ameliorative influence of dietary fenugreek (Trigonella foenumgraecum) seeds and onion (Allium cepa) on eye lens abnormalities via modulation of crystallin proteins and polyol pathway in experimental diabetes. Current Eye Research, 43 (9). pp. 1108-1118.