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Zinc Supplementation Ameliorates Diabetic Cataract Through Modulation of Crystallin Proteins and Polyol Pathway in Experimental Rats.

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Relation http://ir.cftri.com/13907/
https://doi.org/10.1007/s12011-018-1373-3
 
Title Zinc Supplementation Ameliorates Diabetic Cataract
Through Modulation of Crystallin Proteins and Polyol Pathway
in Experimental Rats.
 
Creator Susmita, Barman
Srinivasan, K.
 
Subject 04 Diabetes Mellitus
04 Vitamins
 
Description Non-enzymatic glycation of lens proteins and elevated polyol pathway in the eye lens have been the characteristic features of a
diabetic condition. We have previously reported the benefits of zinc supplementation in reducing hyperglycemia and associated
metabolic abnormalities and oxidative stress in diabetic rats. The current study explored whether zinc supplementation protects
against cataractogenesis through modulation of glycation of lens proteins, elevated polyol pathway, oxidative stress, and proportion
of different heat shock proteins in the eye lens of diabetic rats. Streptozotocin-induced diabetic rats were fed with a zincenriched
diet (5 and 10 times of normal) for 6 weeks. Supplemental zinc alleviated the progression and maturation of diabetesinduced
cataract. Zincwas also effective in preventing the reduced content of total and imbalanced proportion of soluble proteins in
the lens. Supplemental zinc also alleviated cross-linked glycation and concomitant expression of the receptor of glycated products
and oxidative stress indicators in the eye lens. Zinc supplementation further induced the concentration of heat shock protein in the
eye lens of diabetic rats, specifically α-crystallin. Zinc supplementation counteracted the elevated activity and expression of polyol
pathway enzymes and molecules in the lens. The results of this animal study endorsed the advantage of zinc supplementation in
exerting the antiglycating influence and downregulating polyol pathway enzymes to defer cataractogenesis in diabetic rats.
 
Date 2019
 
Type Article
PeerReviewed
 
Format pdf
 
Language en
 
Identifier http://ir.cftri.com/13907/1/Biological%20Trace%20Element%20Research%20%282019%29%20187%20212%E2%80%93223.pdf
Susmita, Barman and Srinivasan, K. (2019) Zinc Supplementation Ameliorates Diabetic Cataract Through Modulation of Crystallin Proteins and Polyol Pathway in Experimental Rats. Biological Trace Element Research, 187. pp. 212-223.