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Prophylactic neuroprotective propensity of Crocin, a carotenoid against rotenone induced neurotoxicity in mice: behavioural and biochemical evidence.

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Relation http://ir.cftri.com/14220/
https://doi.org/10.1007/s11011-019-00451-y
 
Title Prophylactic neuroprotective propensity of Crocin, a carotenoid against rotenone induced neurotoxicity in mice: behavioural and biochemical evidence.
 
Creator Sriranjini, Venkata Rao
Hemalatha, P.
Yetish, S.
Muralidhara, M.
Rajini, P. S.
 
Subject 14 Carotenoid Chemistry
17 Toxicology
 
Description Previously we have demonstrated the potential neuroprotective propensity of saffron and Crocin (CR) employing a Drosophila model of Parkinsonism. Rotenone (ROT) has been extensively used as a model neurotoxin to induce Parkinson’s disease (PD) likesymptomsinmice.In the present study,as a proof of conceptweevaluatedtheefficacyofCRprophylaxis(25mg/kgbw/d, 7d) toattenuate ROT(0.5mg/Kg bw/d,7d) -inducedneurotoxiceffects inmalemicefocussing onneurobehaviouralassessments andbiochemical determinantsinthestriatum.CRprophylaxissignificantlyalleviatedROT-inducedbehaviouralalterationssuch as increased anxiety, diminished exploratory behaviour, decreased motor co-ordination, and grip strength. Concomitantly, we evidenceddiminutionofoxidative stressmarkers,enhancedlevelsofantioxidant enzymeand mitochondrialenzymefunctionin the striatalregion. Further, varying degreeofrestoration ofcholinergic function, dopamineand α-synucleinlevelswerediscerniblesuggestingthepossiblemechanism/sofactionofCRinthismodel.Basedonourearlierdatainfliesandinwormmodel,we propose its use as an adjuvant therapeutic agent in oxidative stress-mediated neurodegenerative conditions such as PD.
 
Date 2019
 
Type Article
PeerReviewed
 
Format pdf
 
Language en
 
Identifier http://ir.cftri.com/14220/1/Metabolic%20Brain%20Disease%20%282020%29%20341341%E2%80%931353.pdf
Sriranjini, Venkata Rao and Hemalatha, P. and Yetish, S. and Muralidhara, M. and Rajini, P. S. (2019) Prophylactic neuroprotective propensity of Crocin, a carotenoid against rotenone induced neurotoxicity in mice: behavioural and biochemical evidence. Metabolic Brain Disease, 34. pp. 1341-1353.