Record Details

Lectin rich horsegram protein and myricetin activates insulin signaling – A study targeting PTP1β.

IR@CSIR-CFTRI

View Archive Info
 
 
Field Value
 
Relation http://ir.cftri.com/14259/
https://doi.org/10.1016/j.jff.2020.103845
 
Title Lectin rich horsegram protein and myricetin activates insulin signaling – A
study targeting PTP1β.
 
Creator Lalitha, N.
Sadashivaiah, B.
Ramaprasad, T. R.
Sridevi Annapurna, Singh
 
Subject 29 Protein Chemistry
22 Legumes-Pulses
 
Description Horsegram, a rich source of myricetin (Myr), exhibits an anti-hyperglycemic effect. We examined the individual
and combinational effect of Myr and horsegram protein (HP) on protein tyrosine phosphatase 1β (PTP1β), and
its effect on insulin signaling in high-fat-diet (HFD) and a single dose of streptozotocin (STZ) induced diabetic rat
model. Myr, HP, and their combination, Myr + HP, were orally administered to diabetic animals for four weeks.
Myr, HP, and Myr + HP were effective in reducing elevated blood glucose, HbA1c, fasting insulin, insulin
resistance, oxidative stress markers, and proinflammatory cytokines. Myr ameliorated dyslipidemia and significantly
reduced PTP1β activity; HP and Myr + HP were not as effective, although they suppressed the expression
of PTP1β. Myr and HP treated groups had elevated levels of the phospho-insulin receptor (pIR),
phospho-insulin receptor substrate1 (pIRS1), and phospho-Akt (pAkt), whereas, Myr + HP was not effective.
Though myricetin and horsegram proteins ameliorate diabetic conditions, dietary intake of their combination
reduced individual efficiency.
 
Publisher Elsevier
 
Date 2020
 
Type Article
PeerReviewed
 
Format pdf
 
Language en
 
Identifier http://ir.cftri.com/14259/1/Journal%20of%20Functional%20Foods%2067%20%282020%29%20103845.pdf
Lalitha, N. and Sadashivaiah, B. and Ramaprasad, T. R. and Sridevi Annapurna, Singh (2020) Lectin rich horsegram protein and myricetin activates insulin signaling – A study targeting PTP1β. Journal of Functional Foods, 67. ISSN 1756-4646