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Safety efficacy and chemical profiling of water-soluble Talaromyces purpureogenus CFRM02 pigment.

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Relation http://ir.cftri.com/14385/
https://doi.org/10.1016/j.foodchem.2019.125869
 
Title Safety efficacy and chemical profiling of water-soluble Talaromyces purpureogenus CFRM02 pigment.
 
Creator Saritha, G. Pandit
Mohan Kumari, H. P.
Muthukumar, S. P.
Mohan, A. Dhale
 
Subject 17 Toxicology
10 Food Microorganisms
 
Description Talaromyces purpureogenus CFRM02 pigments are non-toxic to Artemia franciscana. Further, in acute toxicity study, singledose(50,300,1000and2000mg/kgbodyweight)pigmentwas administeredtofemaleWistarrats. After 14days, no evidence of adverse effect on body weight, mortality and clinical signs were observed. Similarly, 28days sub-acute studies (250–1000mg/kg body weight) showed no significant changes in food intake, body weight gain and relative weight of vital organs. No signs of toxicity on biochemical, hematological parameters. Histopathological examination of the liver and kidney were normal. There were no marked changes in any of these rumen zymes activities.There were no significant changes in treated and control group(acuteand sub-acute). The HRMS data revealed the identification of purpuride, PP-O, PP-R, pentalsamonin, puractin-A, arginine-monascorubrin, purpurquinone-A, ankaflavin, purpactin-C. Theseresults confirmed safety efficacy of T. purpureogenus CFRM02 pigment and suggested applications in food and nutraceuticals.
 
Date 2020
 
Type Article
PeerReviewed
 
Format pdf
 
Language en
 
Identifier http://ir.cftri.com/14385/1/Food%20Chemistry%20310%20%282020%29%20125869.pdf
Saritha, G. Pandit and Mohan Kumari, H. P. and Muthukumar, S. P. and Mohan, A. Dhale (2020) Safety efficacy and chemical profiling of water-soluble Talaromyces purpureogenus CFRM02 pigment. Food Chemistry, 310. ISSN 0308-8146