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Impromptu Effects of Nt8U with Soyasaponins on Obesity-related Lipid Parameters in High Fat Fed C57BL/6 Mice.

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Relation http://ir.cftri.com/14398/
https://doi.org/10.1007/s10989-019-09846-y
 
Title Impromptu Effects of Nt8U with Soyasaponins on Obesity-related Lipid Parameters in High Fat Fed C57BL/6 Mice.
 
Creator Govardhan Singh, R. S.
Uma, V. Manjappara
 
Subject 11 Lipid Biochemistry
05 Soya bean
 
Description Nt8U is a peptide analog of the N-terminal 13 residue fragment of the satiety peptide obestatin with Gly (8) being replaced by α-amino isobutyric acid (Aib). As a consequence of introducing a conformationally constrained, unusual amino acid Aib, it has a longer half-life of 30 min in circulation against 5 min for obestatin. It was found to be as effective as obestatin in modulating lipid parameters favorably in mice. Saponins have also been studied extensively for their anti-obesity effects. Though saponins from soyabean have been reported to have lipid lowering activities, the studies are largely carried out with group B saponins. We hypothesized that Nt8U could be a better anti-obesity lead candidate if co-administered with other lipid lowering nutraceuticals. Hence in the present study, we evaluated the combined effect of Nt8U and the under-exploited soyasaponins on lipid parameters in high fat fed (HFD) C57BL/6 mice. Mice fed HFD for 18 weeks were administered Nt8U with soyasaponins A or B for a period of 8 days. Although there was no significant difference in food intake, Nt8U with soyasaponins A was found to be the best combination that reduced perirenal, retroperitoneal and axillary fat.
 
Date 2020
 
Type Article
PeerReviewed
 
Format pdf
 
Language en
 
Identifier http://ir.cftri.com/14398/1/International%20Journal%20of%20Peptide%20Research%20and%20Therapeutics%20%202020.pdf
Govardhan Singh, R. S. and Uma, V. Manjappara (2020) Impromptu Effects of Nt8U with Soyasaponins on Obesity-related Lipid Parameters in High Fat Fed C57BL/6 Mice. International Journal of Peptide Research and Therapeutics, 26. pp. 405-411.