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Chemical Hybridizing Agents for Chickpea ( Cicer arietinum L.): Leads from QSAR Analysis of Ethyl Oxanilates and Pyridones

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Relation http://eprints.cmfri.org.in/9949/
 
Title Chemical Hybridizing Agents for Chickpea ( Cicer arietinum L.):
Leads from QSAR Analysis of Ethyl Oxanilates and Pyridones
 
Creator Chakraborty, Kajal
Devakumar, C
 
Subject Bioactive compound
 
Description In the self-pollinated crops such as chickpea, induction of male sterility by deployment of chemical
hybridizing agents (CHAs) facilitating “two-line” approach holds immense potential in heterosis
breeding. A total of 40 test CHAs comprising 20 ethyl oxanilates and 20 pyridones were screened as
potential CHAs on chickpea (variety BG 1088) at 500, 800, and 1000 ppm. Three test compounds
mostly having either F (4)/Br (5)/CF3 (19) at the paraposition of the aryl ring from a pool of 20 ethyl
oxanilates were identified as the most potent CHAs causing g99% induction of pollen sterility and
>90% total flower sterility at 1000-ppm test concentration. Among pyridone derivatives, N-(4-
chlorophenyl)-5-carbethoxy-4,6-dimethyl, 1,2-dihydropyrid-2-one (26) was found to be the most active.
Quantitative structure activity relationship (QSAR) analysis has revealed a direct involvement of
Swain-Lupton field constant, Fp, with the target bioactivity which implied that field rather than
resonance effect ( R) had a positive effect on the activity. The real guiding principle for selectivity was
found out to be the hydrophobic parameter ð value. The QSAR models indicated that increased
steric bulk at the 4-position on the phenyl ring is associated with enhanced activity. The CHAs appeared
to act by mimicking UDP-glucose, the key substrate in the synthesis of callose, or lead to an imbalance
in acid-base equilibrium in pollen mother cells resulting in dissolution of callose wall by premature
callase secretion.
 
Publisher American Chemical Society
 
Date 2006
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
Identifier http://eprints.cmfri.org.in/9949/1/1.pdf
Chakraborty, Kajal and Devakumar, C (2006) Chemical Hybridizing Agents for Chickpea ( Cicer arietinum L.): Leads from QSAR Analysis of Ethyl Oxanilates and Pyridones. Journal of Agricultural and Food Chemistry, 54. pp. 1868-1873.