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Biochemical Studies on the Antiulcer Effect of Glucosamine on Antioxidant Defense Status in Experimentally Induced Peptic Ulcer in Rats

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Title Biochemical Studies on the Antiulcer Effect of Glucosamine on Antioxidant Defense Status in Experimentally Induced Peptic Ulcer in Rats
Not Available
 
Creator Santhosh, S.
Anandan, R.
Sini, T. K.
Mathew, P. T.
Thankappan, T. K.
 
Subject glucosamine
ibuprofen
ulcer
acid out put
antioxidant status
 
Description Not Available
The present study examined the antiulcer effect of glucosamine on mucosal antioxidant defense system in ibuprofen-induced peptic ulcer in male albino rats. The number of lesions in the gastric mucosa, volume of gastric juice, acid output, pepsin activity, lipid peroxides, reduced glutathione content and the activities of glutathione dependent antioxidant enzymes glutathione peroxidase and glutathione- SPrior oral administration of glucosamine significantly prevented the ibuprofen-induced increases in the number of lesions in the gastric mucosa, volume of gastric juice and acidity. pepsin at near normal level. Oral pretreatment of glucosamine exerted a significant antioxidant effect by preventing ibuprofen-induced lipid peroxidation and by maintaining the level of reduced glutathione and the activities of mucosal antioxidant enzymes at near normalcy. antiulcer activity of glucosamine is related to its ability to neutralize the hydrochloric acid secreted into the stomach and to its antioxidant capability to inhibit ibuprofen-induced lipid peroxidation.
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Date 2022-09-16T10:26:15Z
2022-09-16T10:26:15Z
2005
 
Type Research Paper
 
Identifier Santhosh, S., Anandan, R., Sini, T. K., Mathew, P. T. and Thankappan, T. K. (2005) Biochemical Studies on the Antiulcer Effect of Glucosamine on Antioxidant Defense Status in Experimentally Induced Peptic Ulcer in Rats. Journal of Clinical Biochemistry and Nutrition. 37(2): 61-66.
0912-0009
http://krishi.icar.gov.in/jspui/handle/123456789/74276
 
Language English
 
Relation Not Available;
 
Publisher J Stage