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GC-MS/MS Based Phytochemical Screening of Therapeutic Potential of Calligonum polygonoides L. Flower Bud Against Chronic Diseases

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Title GC-MS/MS Based Phytochemical Screening of Therapeutic Potential of Calligonum polygonoides L. Flower Bud Against Chronic Diseases
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Creator MK Berwal, Haldhar SM, Chet Ram, Gora JS, Singh D and Samadia DK
 
Subject Bioactive compounds, Calligonum polygonoides, GC‑MS/MS, pharmaceutical applications, phog, phytochemical screening
 
Description Not Available
Background: Calligonum polygonoides is an endemic plant species,
belongs to Polygonaceae family, native to the “Thar Desert” of India.
It is highly tolerant to multiple stresses with dominant biomass
and phytochemical producer under extreme niche. It has significant
ethnopharmacological applications, but not yet scientifically validated.
Materials and Methods: The methanolic extract of C. polygonoides flower
bud was subjected to gas chromatography mass spectroscopy (GC‑MS)
analysis and antioxidant potential assay was done on different radical
scavenging scales. The phytochemicals were identified based on retention
time and matching their mass spectra to spectra in NIST 14 library.
Results: The results revealed the presence of fatty acids, phenolics,
terpenoides, flavanoids, alkaloids, tannins, steroids, ketones, esters, and
amino acid derivatives, which comprises 93 compounds. Most of the
detected compounds have been proved to possess important bio‑activities
such as anti‑microbial, anti‑inflammatory, anticancer, anti‑diabetic,
hepatoprotective, cardiovascular, antioxidant, and antimutagenic.
Interestingly, some compounds such as furan‑2,5‑dimethyl, 2,3-dihydro-2,5-
dihydroxy-6 -methyl-4H-pyran-4-one (DDMP), dehydromevalonic lactone,
deoxyspergualin, 2‑methoxy‑4‑vinylphenol, benzeneethanol‑4‑hydroxy‑,
quinic acid, lauric acid, linolenic acid, and squalene were detected which
have proved pharmaceuticals applications against major diseases such
as cancer, diabetics, cardiovascular, and some other chronic diseases.
Furthermore, the methanolic extract also attributed very high level of
antioxidant potential on cupric reducing antioxidant capacity, ferric reducing
antioxidant power, 2,2‑diphenyl‑1‑picrylhydrazyl, and phosphomolybdenum
assay scales. Conclusion: The identified phytochemicals with ample
pharmaceutical application explore the worthiness of this endemic
plant species. Along with pharmaceutical, it has an immense scope in
nutraceutical and functional food industry. These medicinal importance
advised for its conservation and artificial regeneration, to sustain the
agro‑ecological balance of Thar Desert of India.
Not Available
 
Date 2021-07-09T06:24:17Z
2021-07-09T06:24:17Z
2021-06-10
 
Type Article
 
Identifier Berwal MK, Haldhar SM, Ram C, Gora JS, Singh D, Samadia DK. GC-MS/MS-based phytochemical screening of therapeutic potential of Calligonum polygonoides L. flower bud against chronic diseases. Phcog Mag 2021;17:S68-76.
Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/47579
 
Language English
 
Relation Not Available;
 
Publisher Wolters Kluwer - Medknow