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Tomato auxin biosynthesis/signaling is reprogrammed by the geminivirus to enhance its pathogenicity

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Title Tomato auxin biosynthesis/signaling is reprogrammed by the geminivirus to enhance its pathogenicity
Not Available
 
Creator Vinutha T., Vanchinathan S., Bansal N., Kumar G., Permar V., Watts A., Ramesh S.V. Praveen S.
 
Subject ToLCNDV, Pathogenicity factor, Phytohormones, AC4, miRNAs,Host–virus interactions
 
Description Not Available
Main conclusion Tomato leaf curl New Delhi virus-derived AC4 protein interacts with host proteins involved in
auxin biosynthesis and reprograms auxin biosynthesis/signaling to help in viral replication and manifestation of the
disease-associated symptoms.
Abstract Perturbations of phytohormone-mediated gene regulatory network cause growth and developmental defects. Furthermore, plant viral infections cause characteristic disease symptoms similar to hormone-defcient mutants. Tomato leaf
curl New Delhi Virus (ToLCNDV)-encoded AC4 is a small protein that attenuates the host transcriptional gene silencing,
and aggravated disease severity in tomato is correlated with transcript abundance of AC4. Hence, investigating the role of
AC4 in pathogenesis divulged that ToLCNDV-AC4 interacted with host TAR1 (tryptophan amino transferase 1)-like protein,
CYP450 monooxygenase—the key enzyme of indole acetic acid (IAA) biosynthesis pathway—and with a protein encoded
by senescence-associated gene involved in jasmonic acid pathway. Also, ToLCNDV infection resulted in the upregulation of
host miRNAs, viz., miR164, miR167, miR393 and miR319 involved in auxin signaling and leaf morphogenesis concomitant
with the decline in endogenous IAA levels. Ectopic overexpression of ToLCNDV-derived AC4 in tomato recapitulated the
transcriptomic and disruption of auxin biosynthesis/signaling features of the infected leaves. Furthermore, exogenous foliar
application of IAA caused remission of the characteristic disease-related symptoms in tomato. The roles of ToLCNDV-AC4
in reprogramming auxin biosynthesis, signaling and cross-talk with JA pathway to help viral replication and manifest the
disease-associated symptoms during ToLCNDV infection are discussed.
Not Available
 
Date 2021-07-30T04:56:40Z
2021-07-30T04:56:40Z
2020-09-17
 
Type Article
 
Identifier Not Available
Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/51361
 
Language English
 
Relation Not Available;
 
Publisher Not Available