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Noncoding RNA-Based Genetically Modified Crops: Concepts and Challenges

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Title Noncoding RNA-Based Genetically Modified Crops: Concepts and Challenges
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Creator S.V. Ramesh, and Shelly Praveen
 
Subject non-coding RNAs, Genetic modification, ERA
 
Description Not Available
In addition to expression of foreign proteins, crop genetic engineering based on small noncoding RNAs (sncRNAs) form an integral component of crop improvement programs. ncRNA-based genetic manipulation is a potent gene silencing tool whenever repression of gene(s) is desired. Gene silencing is achieved mainly by deploying sncRNAs like small interfering RNAs (siRNAs) and artificial miRNAs (amiRNAs). It also offers an opportunity for crop metabolic engineering employing synthetic trans-acting siRNAs (syn-tasiRNAs). Since ncRNA-based genetically modified (GM) crops differ significantly from first-generation protein-based transgenics, there are many apprehensions with regard to off-target and nontarget effects as well as mutational effects on the efficacy of ncRNA silencing, etc. Despite the apprehensions associated with ncRNA-based GM crops, the technology has been successfully employed for crop genetic engineering in 12 crops, incorporating traits ranging from resistance to pathogen, allergen removal, nutritional improvement, etc. The chapter discusses other pertinent issues like persistence of ncRNAs, food and feed safety, and future prospects of ncRNA-based GM crops.
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Date 2021-07-30T04:50:43Z
2021-07-30T04:50:43Z
2015-10-01
 
Type Book chapter
 
Identifier Not Available
Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/51335
 
Language English
 
Relation Not Available;
 
Publisher Elsevier