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Endophytic actinobacteria: Diversity, secondary metabolism and mechanisms to unsilence biosynthetic gene clusters

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Title Endophytic actinobacteria: Diversity, secondary metabolism and mechanisms to unsilence biosynthetic gene clusters
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Creator R Dinesh, V Srinivasan, Sheeja T. E., M Anandaraj & Hamza S
 
Subject Actinobacteria; biosynthetic gene clusters; endophytes; next generation sequencing; secondary metabolites
 
Description Not Available
Endophytic actinobacteria, which reside in the inner tissues of host plants, are gaining serious
attention due to their capacity to produce a plethora of secondary metabolites (e.g. antibiotics)
possessing a wide variety of biological activity with diverse functions. This review encompasses
the recent reports on endophytic actinobacterial species diversity, in planta habitats and mechanisms
underlying their mode of entry into plants. Besides, their metabolic potential, novel bioactive
compounds they produce and mechanisms to unravel their hidden metabolic repertoire by
activation of cryptic or silent biosynthetic gene clusters (BGCs) for eliciting novel secondary
metabolite production are discussed. The study also reviews the classical conservative techniques
(chemical/biological/physical elicitation, co-culturing) as well as modern microbiology tools (e.g.
next generation sequencing) that are being gainfully employed to uncover the vast hidden scaffolds
for novel secondary metabolites produced by these endophytes, which would subsequently
herald a revolution in drug engineering. The potential role of these endophytes in the agro-environment
as promising biological candidates for inhibition of phytopathogens and the way forward
to thoroughly exploit this unique microbial community by inducing expression of cryptic BGCs
for encoding unseen products with novel therapeutic properties are also discussed.
Not Available
 
Date 2021-08-07T18:08:59Z
2021-08-07T18:08:59Z
2017-03-30
 
Type Review Paper
 
Identifier Not Available
Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/53622
 
Language English
 
Relation Not Available;
 
Publisher Taylor & Francis