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Antimicrobial Susceptibility Testing and Biofilm Production of Burkholderia cepacia Complex Organisms from Ultrasound Gels in In

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Title Antimicrobial Susceptibility Testing and Biofilm Production of Burkholderia cepacia Complex Organisms from Ultrasound Gels in In
Not Available
 
Creator Ravichandran Karthikeyan, Bhoj R Singh*, Akanksha Yadav, Himani Agri, Varsha Jayakumar, Vinodhkumar OR, Dharmendra K Sinha
 
Subject Antimicrobial Susceptibility Testing and Biofilm Production of Burkholderia cepacia Complex Organisms from Ultrasound Gels in India
 
Description Not Available
Burkholderia cepacia complex (Bcc) bacteria are versatile difficult to treat pathogens with extraordinary metabolic diversity. They
are important nosocomial pathogens having multi-drug resistant potential. Contamination and biofilm formation on medical devices
and equipment are the important reasons for the multiple outbreaks in recent decades. In this study, we subjected 32 isolates of Bcc
to the two important virulent traits such as antimicrobial susceptibility and biofilm producing ability with and without different
stress conditions. All the isolates were susceptible to co-trimoxazole (TMP-SMX) (100%) suggesting it as the preferred drug or the
drug of the first choice for treating Bcc from ultrasound gels infections. The isolates showed the varied degree of susceptibility to
meropenem (91%), doxycycline (85%), gatifloxacin (85%), piperacillin+ tazobactam (82%), ceftazidime (79%), and levofloxacin
(71%). Multiple antibiotic resistance (MAR) indices for all the isolates were >0.2 and three isolates had >0.5. Most of the Bcc isolates
(81.25%) were weak biofilm producers, while three strains each of B.cepacia, B. cenocepacia and B. pseudomultivorans produced
moderate and strong types of biofilms under standard laboratory conditions. The combination of change in pH with other stress
conditions significantly increased the biofilm formation. This study found the difference in the antimicrobial susceptibility pattern
of Bcc isolates from ultrasound gels and the adaptability to in-vitro stress conditions explaining the variability of virulence among
Bcc species.
Keywords: Burkholderia cepacia Complex (Bcc); Ultrasound Gels; Antimicrobial Susceptibility Testing; Multiple Antibiotic Resistance
Not Available
 
Date 2023-06-07T03:49:52Z
2023-06-07T03:49:52Z
2023-03-02
 
Type Article
 
Identifier Not Available
Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/78073
 
Language English
 
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Publisher Not Available