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Characterization and antibacterial activity of melanin pigment from marine bacterium Actinoalloteichus cyanogriseus

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Title Characterization and antibacterial activity of melanin pigment from marine bacterium Actinoalloteichus cyanogriseus
Not Available
 
Creator Muddukrishnaiah Kotakonda
Makesh Marappan
Bhaskar Biswas
 
Subject Antibacterial Activity
Melanin Pigment
Actinoalloteichus Cyanogriseus
 
Description Not Available
Introduction: Marine microbes are known to produce novel bioactive compounds. In this work, the
bacterium Actinoalloteichus cyanogriseus, AU-RM-4, isolated from marine soil sediment, capable of
producing high amounts of black extracellular melanin pigment when grown on anaerobic
actinomycetes agar is reported. The maximum melanin production was approximately 2.5 mg/mL.
Methods: The melanin pigment was recovered using acid treatment and the characteristic melanin
absorption peaks at 253 nm and 291 nm were observed in the UV range. The antibacterial activity of
the melanin pigment against a range of clinically infectious bacteria was assayed in vitro by disc
diffusion and serial dilution methods.
Results: The A. cyanogriseus melanin showed antimicrobial activity against Staphylococcus aureus
and Klebsiella pneumoniae (MIC value -500 μg/mL). The effects of the AU-RM-4 melanin on the
morphology of pathogenic bacteria were observed under scanning (SEM) and transmission electron
microscopy (TEM). It is concluded that A. cyanogriseus isolate AU-RM-4 is a promising melaninproducing
marine bacterium, whose melanin pigment has antibacterial activity against certain
pathogenic bacteria (S. aureus and K. pneumoniae).
Conclusion: Melanin produced by A. cyanogriseus AU-RM-4 could have commercial potential in the
pharmaceutical and cosmetic industries for the production of pharmaceutical formulations, and also
in the food industries as a colouring and antibacterial agent.
Not Available
 
Date 2023-06-09T04:30:06Z
2023-06-09T04:30:06Z
2023-01-01
 
Type Book
 
Identifier Not Available
Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/78167
 
Language English
 
Relation Not Available;
 
Publisher Not Available