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Bacterial bioactive metabolites as therapeutic agents: From production to action

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Title Bacterial bioactive metabolites as therapeutic agents: From production to action
Not Available
 
Creator Arun, K. B.
Sindhu, R.
Alex, D.
Binod, P.
Pughazhendi, A.
Joseph, T.C.
Pandey, A.
Kuddus, M.
Pillai, S.
Emmanual, S.
Awasthi, M. K.
Madhavan, A.
 
Subject Not Available
 
Description Not Available
Bacterial metabolites are one of the primary sources of drugs that we currently use to treat several diseases. However, bacterial drug discovery and development is a challenging and time-consuming process, and the emergence of new diseases and the development of resistance to currently available drugs demand the discovery of new metabolites with better biological activities. The new advancements in microbial technology, omics, genome and metabolic engineering, synthetic biology and the interdisciplinary approach of these fields overcome the hurdles in drug discovery and heterologous synthesis from bacteria. The gut microbiome performs a vital role in sustaining human health and aids in tackling various diseases. The metabolites produced by the gut microbiome act as an energy source for colon epithelium, maintain pH, help in cell differentiation and induces apoptosis in abnormal cells. The review discusses about the bacterial derived bioactive compounds, advancements and technologies in bacterial synthesis of bioactive sources and genomic and synthetic biology methods for the bioprospecting of bacterial metabolites. Since the gut microbiome relates to colon health, we have also discussed the techniques comprising probiotics, prebiotics, microbiome transplantation, toxins, and bacteriocins capable of preventing and managing colon associated health condition. Future directions in bacterial bioactive metabolite production are also discussed.
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Date 2023-06-23T03:53:38Z
2023-06-23T03:53:38Z
2022-06
 
Type Research Paper
 
Identifier Arun, K. B., Sindhu, R., Alex, D., Binod, P., Pughazhendi, A., Joseph, T.C., Pandey, A., Kuddus, M., Pillai, S., Emmanual, S., Awasthi, M. K. and Madhavan, A. (2022) Bacterial bioactive metabolites as therapeutic agents: From production to action. Sustain Chem Pharm. 27: 100650.
2352-5541
http://krishi.icar.gov.in/jspui/handle/123456789/78877
 
Language English
 
Relation Not Available;
 
Publisher Elsevier