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Hepatorenal Toxicity of Inorganic Arsenic in White Pekin Ducks and Its Amelioration by Using Ginger

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Title Hepatorenal Toxicity of Inorganic Arsenic in White Pekin Ducks and Its Amelioration by Using Ginger
 
Creator Santosh Kumar panda
Dhirendra Kumar
Geeta Rani Jena
Ramesh Chandra Patra
Susen Kumar panda
Kamdev sethy
S.K. Mishra
B.K.Swain
P.K. Naik
C.K. Beura
Bhagyalaxmi Panda
 
Subject Arsenic ? Ginger ? Duck ? Nrf2-Keap-1 ? NF-?B ? Hepato-renal
 
Description Not Available
The toxic metalloid arsenic is known to cause liver and kidney injury in many humans and animals. The goal of this paper was to exemplify the antagonism of ginger against arsenic (As)-induced hepato-renal toxicity. In addition, the pathways Nrf2/Keap1 and NF/?B were studied to reveal the molecular mechanism of the stress. One hundred twenty 7-day-old White Pekin ducks were randomly allocated into five groups, having 24 birds in each. Each group contained three replicates having 8 birds in each replicate and maintained for 90 days. The groups were as follows: T-1 [control-basal diet with normal water], T-2 [T1?+?As at 28 ppm/L of water], T-3 [T2?+?ginger powder at 100 mg/kg feed], T-4 [T2?+?ginger powder at 300 mg/kg feed], and T-5 [T2?+?ginger powder at 1 g/kg feed]. It was observed that there was a significant increase in oxidative parameters whereas a significant decrease in antioxidant parameters in hepato-renal tissues in T-2. The exposure to As not only decreased the mRNA expression of antioxidant parameters like Nrf2, SOD-1, CAT, GPX, and HO-1and anti-inflammatory markers like IL-4 and IL-10 but also increased the m-RNA expression of NF-?B, Keap-1 and pro-inflammatory markers like IL-2, Il-6, IL-18, IL-1?, and TNF-?. There was also an accumulation of As in hepatic and renal tissue, confirmed by residual analysis of these tissues. By correlating the above parameters, As at 28 ppm showed significant toxic effects, and ginger powder at 1 g/kg feed effectively counteracted the toxic effects of As in ducks.
 
Date 2023-07-25T07:20:41Z
2023-07-25T07:20:41Z
2022-6-20
 
Type Research Paper
 
Identifier —
Not Available
0163-4984
http://krishi.icar.gov.in/jspui/handle/123456789/80184
 
Language English
 
Relation —
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Publisher Not Available