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http://krishi.icar.gov.in/jspui/handle/123456789/26681| Title: | FMRP Interacts with C/D Box snoRNA in the Nucleus and Regulates Ribosomal RNA Methylation |
| Other Titles: | Not Available |
| Authors: | Michelle Ninochka D'Souza, Naveen Kumar Chandappa Gowda, Vishal Tiwari, Rosana Ottakandathil Babu, Praveen Anand, Sudhriti Ghosh Dastidar, Randhir Singh, Bhuvaneish Selvaraja, Rakhi Pal, Arati Ramesh, Sumantra Chattarji, Siddharthan Chandran, Akash Gulyani, Dasaradhi Palakodeti, Ravi S Muddashetty |
| ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
| Author's Affiliated institute: | ICAR::Indian Institute of Soil Science |
| Published/ Complete Date: | 2018-11-30 |
| Project Code: | Not Available |
| Keywords: | Not Available |
| Publisher: | Elsevier |
| Citation: | 1 |
| Series/Report no.: | Not Available; |
| Abstract/Description: | FMRP is an RNA-binding protein that is known to localize in the cytoplasm and in the nucleus. Here, we have identified an interaction of FMRP with a specific set of C/D box snoRNAs in the nucleus. C/D box snoRNAs guide 2’O methylations of ribosomal RNA (rRNA) on defined sites, and this modification regulates rRNA folding and assembly of ribosomes. 2’O methylation of rRNA is partial on several sites in human embryonic stem cells, which results in ribosomes with differential methylation patterns. FMRP-snoRNA interaction affects rRNA methylation on several of these sites, and in the absence of FMRP, differential methylation pattern of rRNA is significantly altered. We found that FMRP recognizes ribosomes carrying specific methylation patterns on rRNA and the recognition of methylation pattern by FMRP may potentially determine the translation status of its target mRNAs. Thus, FMRP integrates its function in the nucleus and in the cytoplasm. |
| Description: | Not Available |
| ISSN: | Not Available |
| Type(s) of content: | Research Paper |
| Sponsors: | Not Available |
| Language: | English |
| Name of Journal: | iScience |
| Volume No.: | Volume 9 |
| Page Number: | Pages 399-411 |
| Name of the Division/Regional Station: | Not Available |
| Source, DOI or any other URL: | https://doi.org/10.1016/j.isci.2018.11.007 https://scholar.google.com/scholar?oi=bibs&cluster=16558813550195365201&btnI=1&hl=en |
| URI: | http://krishi.icar.gov.in/jspui/handle/123456789/26681 |
| Appears in Collections: | NRM-IISS-Publication |
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