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http://krishi.icar.gov.in/jspui/handle/123456789/42340| Title: | Muscle transcriptome signature and gene regulatory network in two divergent lines of a semi-domesticated bovine Mithun (Bos frontalis) |
| Other Titles: | Not Available |
| Authors: | Sabyasachi Mukherjee Anupama Mukherjee Rahul Singh Jasrotia Sarika Jaiswal M. A. Iquebal Imsusosang Longkumer Moonmoon Mech Kezhavituo Vüpru Kobu Khate Chandan Rajkhowa Anil Rai Dinesh Kumar |
| ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
| Author's Affiliated institute: | ICAR::Indian Agricultural Statistics Research Institute |
| Published/ Complete Date: | 2019-01-01 |
| Project Code: | Not Available |
| Keywords: | Bos frontalis de novo assembly Marker discovery Gene regulatory network Transcriptome |
| Publisher: | Not Available |
| Citation: | Not Available |
| Series/Report no.: | Not Available; |
| Abstract/Description: | A massive bovine, Bos frontalis, also known as Mithun or Gayal, found at higher altitude is very promising meat and milk animal. For candidate gene and marker discovery, RNA-seq data was generated from longissimus dorsi muscle tissues with Illumina-HiSeq. Such markers can be used in future for genetic gain of traits like feed conversion efficiency (FCE) and average daily gain (ADG). Analysis revealed 297differentially expressed genes (DEGs) having 173 up and 124 down-regulated unigenes. Extensive conservation was found in genic region while comparing with Bos taurus. Analysis revealed 57 pathways having 112 enzymes, 72 transcriptional factors and cofactors, 212 miRNAs regulating 71 DEGs, 25,855 SSRs, mithun-specific 104,822 variants and 7288 indels, gene regulatory network (GRN) having 24 hub-genes and transcriptional factors regulating cell proliferation, immune tolerance and myogenesis. This is first report of muscle transcriptome depicting candidate genes with GRN controlling FCE and ADG. Reported putative molecular markers, candidate genes and hub proteins can be valuable genomic resources for association studies in genetic improvement programme. |
| Description: | Not Available |
| ISSN: | Not Available |
| Type(s) of content: | Article |
| Sponsors: | Not Available |
| Language: | English |
| Name of Journal: | Genomics |
| NAAS Rating: | 12.21 |
| Volume No.: | 112(2020) |
| Page Number: | 252-262 |
| Name of the Division/Regional Station: | Not Available |
| Source, DOI or any other URL: | Not Available |
| URI: | http://krishi.icar.gov.in/jspui/handle/123456789/42340 |
| Appears in Collections: | AEdu-IASRI-Publication |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Muscle transcriptome signature and gene regulatory network in two divergent lines of a semi-domesticated bovine Mithun (Bos frontalis).pdf | 3.52 MB | Adobe PDF | View/Open |
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