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http://krishi.icar.gov.in/jspui/handle/123456789/52717| Title: | Antioxidant defense of betaine against isoprenaline-induced myocardial infarction in rats |
| Other Titles: | Not Available |
| Authors: | Ganesan, B. Buddhan, S. Anandan, R. Sivakumar, R. AnbinEzhilan, R. |
| ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
| Author's Affiliated institute: | Vinayaka Missions University, Ariyanoor, Salem 636308, Tamil Nadu, India ICAR::Central Institute of Fisheries Technology |
| Published/ Complete Date: | 2009-03-15 |
| Project Code: | Not Available |
| Keywords: | Betaine Isoprenaline Myocardial infarction Lipid peroxidation Antioxidant status |
| Publisher: | Springer |
| Citation: | Ganesan, B., Buddhan, S., Anandan, R., Sivakumar, R., AnbinEzhilan, R. (2010) Antioxidant defense of betaine against isoprenaline-induced myocardial infarction in rats. Mol Biol Rep., 37(3): 1319–1327. |
| Series/Report no.: | Not Available; |
| Abstract/Description: | We investigated the antioxidant preventive effect of betaine on isoprenaline-induced myocardial infarction in male albino rats. Isoprenaline induced myocardial infarction was manifested by a moderate elevation in the levels of diagnostic marker enzymes and homocysteine in plasma of experimental rats. Significant rise in the level of lipid peroxidation with a concomitant decline in the levels of myocardial non-enzymic and enzymic antioxidants was also observed. Oral pretreatment with betaine significantly prevented isoprenaline-induced alterations in the levels of diagnostic marker enzymes and homocysteine in plasma of experimental groups of rats. It counteracted the isoprenaline-induced lipid peroxidation and maintained the myocardial antioxidant defense system at near normal. Histopathological observations also confirmed the protective effect of betaine against isoprenaline-induced myocardial infarction. The results of the present investigation indicate that the protective effect of betaine is probably related to its ability to strengthen the myocardial membrane by its membrane stabilizing action or to a counteraction of free radicals by its antioxidant property. |
| Description: | Not Available |
| ISSN: | 0301-4851 (print); 1573-4978 (web) |
| Type(s) of content: | Research Paper |
| Sponsors: | Not Available |
| Language: | English |
| Name of Journal: | Molecular Biology Reports |
| NAAS Rating: | 7.4 |
| Volume No.: | 37(3) |
| Page Number: | 1319-1327 |
| Name of the Division/Regional Station: | Not Available |
| Source, DOI or any other URL: | https://doi.org/10.1007/s11033-009-9508-4 |
| URI: | http://krishi.icar.gov.in/jspui/handle/123456789/52717 |
| Appears in Collections: | FS-CIFT-Publication |
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