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http://krishi.icar.gov.in/jspui/handle/123456789/52718| Title: | Biochemical studies on the cardioprotective effect of squalene against Isoprenaline induced myocardial infraction in rats |
| Other Titles: | Not Available |
| Authors: | Sabeena Farvin, K. H. Anandan, R. Kumar, S. H. S. Suseela Mathew Sankar, T. V. Viswanathan Nair, P. G. |
| ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
| Author's Affiliated institute: | ICAR::Central Institute of Fisheries Technology |
| Published/ Complete Date: | 2009-04 |
| Project Code: | Not Available |
| Keywords: | Squalene myocardial infarction cholesterol lipid peroxidation |
| Publisher: | Society of Fisheries Technologists (India) |
| Citation: | Sabeena Farvin, K. H., Anandan, R., Kumar, S. H. S., Suseela Mathew, Sankar, T. V. and Viswanathan Nair, P. G. (2009) Biochemical studies on the cardioprotective effect of squalene against Isoprenaline induced myocardial infraction in rats. Fish Tech. 46(2): 139-151. |
| Series/Report no.: | Not Available; |
| Abstract/Description: | This study was designed to examine the cardioprotective effect of squalene against isoprenaline-induced myocardial infarction in male albino rats. Levels of diagnostic markers [troponin T, homocysteine], lipoproteins [apolipoprotein Al, apolipoprotein B, lipoprotein (a)] (in plasma), total cholesterol, lipid peroxides (in plasma and heart tissue), and endogenous non-enzymatic antioxidants [vitamin C and vitamin EJ (in heart tissue)] were determined. Supplementation of squalene at 2% level along with feed for 45 days significantly prevented the isoprenaline-induced elevation in the diagnostic markers in plasma of experimental group of rats. It exerted an antilipidemic action against isoprenaline-induced hypercholesterolemia by maintaining the levels of cholesterol and lipoprotein components at near normalcy. Squalene supplementation exhibited an antioxidant effect against isoprenaline-induced myocardial infarction by blocking the induction of lipid peroxidation. A tendency to prevent the isoprenaline induced reduction in the non-enzymatic antioxidants such as vitamin E and C was also observed. The results of the present study indicate that the cardioprotective effect of squalene might be ascribable to its antilipidemic, antioxidant and membrane stabilizing properties. |
| Description: | Not Available |
| ISSN: | 0015-3001 |
| Type(s) of content: | Research Paper |
| Sponsors: | Not Available |
| Language: | English |
| Name of Journal: | Fishery Technology |
| Journal Type: | National Journal |
| NAAS Rating: | 5.82 |
| Impact Factor: | 0 |
| Volume No.: | 46(2) |
| Page Number: | 139-151 |
| Name of the Division/Regional Station: | Not Available |
| Source, DOI or any other URL: | Not Available |
| URI: | http://krishi.icar.gov.in/jspui/handle/123456789/52718 |
| Appears in Collections: | FS-CIFT-Publication |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Biochemical studies on the cardioprotective effect of squalene against isoprenaline-induced myocardial infarction in rats.pdf | 928.63 kB | Adobe PDF | View/Open |
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