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http://krishi.icar.gov.in/jspui/handle/123456789/63991
Title: | Unprecedented antioxidative and anti-inflammatory aryl polyketides from the brown seaweed Sargassum wightii |
Other Titles: | Not Available |
Authors: | Chakraborty,Kajal Anusree,M |
ICAR Data Use Licennce: | Not Available |
Author's Affiliated institute: | Not Available |
Published/ Complete Date: | 2017 |
Project Code: | Not Available |
Keywords: | Brown seaweedSargassum wightiiAryl polyketide lactones4-(8-ethyl-tetrahydro-7-oxo-2H-pyran-5-yl)-propyl-4′-methylbenzoateMethyl-2-(12-oxo-7-phenyl-8-vinyl-1-oxa-4, 9-cyclododecadien-3-yl)-acetateAnti-inflammatory activity |
Publisher: | Not Available |
Citation: | Not Available |
Series/Report no.: | Not Available |
Abstract/Description: | Previously undescribed aryl polyketide lactones, 4-(8-ethyl-tetrahydro-7-oxo-2H-pyran-5-yl)-propyl-4′-methylbenzoate (compound 1) and methyl-2-(12-oxo-7-phenyl-8-vinyl-1-oxa-4,9-cyclododecadien-3-yl)-acetate (compound 2) were purified from ethyl acetate-methanol fraction of the brown seaweed Sargassum wightii. The structures were proposed based on their NMR and mass spectrometric data. The antioxidative activities of the lactones were significantly greater (P < 0.05) (IC50 1,1-diphenyl-2-picrylhydrazyl radical scavenging 0.24–0.32 mg/mL) than α-tocopherol (IC50 0.63 mg/mL). The title compounds displayed considerably greater 5- lipoxygenase inhibitory activity (IC50 0.56 and 0.29 mg/mL, respectively) in conjunction with higher selectivity indices (anti-cycloxygense-1IC50/anti-cycloxygense-2IC50> 1) compared to non-steroidal anti-inflammatory drugs (SIaspirin 0.03, SIibuprofen 0.43). Putative biosynthetic pathway of title polyketide products through polyketide synthase enzyme cascade catalyzed reactions substantiated the structural attributions of the hitherto unreported aryl polyketides. This is the first report of the occurrence and characterization of two rare skeletal types, oxo-2H-pyranyl and oxa-cyclododecadienyl macrolactone featuring the aryl substituent from marine organisms with potential antioxidative and anti-inflammatory activities. |
Description: | Not Available |
ISSN: | 0963-9969 |
Type(s) of content: | Article |
Sponsors: | Not Available |
Language: | English |
Name of Journal: | Food Research International |
Volume No.: | 100 |
Page Number: | 640-649 |
Name of the Division/Regional Station: | Not Available |
Source, DOI or any other URL: | http://www.sciencedirect.com/science/article/pii/S096399691730323X http://eprints.cmfri.org.in/12153/1/Food Research International_2017-100-Anusree_Kajal Chakraborty_Unprecedented antioxidative and anti-inflammatory aryl polyketides.pdf |
URI: | http://krishi.icar.gov.in/jspui/handle/123456789/63991 |
Appears in Collections: | FS-CMFRI-Publication |
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