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Title: | Antioxidative and anti-inflammatory pyranoids and isochromenyl analogues from Corbiculid bivalve clam, Villorita cyprinoides |
Other Titles: | Not Available |
Authors: | Joy,Minju Chakraborty,Kajal |
ICAR Data Use Licennce: | Not Available |
Author's Affiliated institute: | Not Available |
Published/ Complete Date: | 2018 |
Project Code: | Not Available |
Keywords: | Corbiculid bivalve clam Villorita cyprinoides Isochromenyl-meroterpenoids Furano-meroterpenoid Antioxidant Functional food components |
Publisher: | Elsevier |
Citation: | Not Available |
Series/Report no.: | Not Available |
Abstract/Description: | Bivalve black clam, Villorita cyprinoides is traditional seafood in Southwestern coast of Arabian Sea. In this study, bioactivity - guided purification of ethyl acetate:methanol extract of black clam was carried out. Two irregular meroterpenoids [tetrahydro - 3 - methoxy - 5 - ((E) - 8,12 - dimethyloct - 8 - enyl) - pyran - 2 - one (1) and dihydro - 5 - (8 - (9,12 - dihydro - 8 - methyl - 11 - propyl - 2H - pyran - 8 - yl) - ethyl) - furan - 2(3H) - one (2)] and two hexahydro - isochromenyl - meroterpenoids (3–4) were identified. The structures were characterized by detailed spectroscopy and their antioxidant / anti - inflammatory potentials were evaluated. Compound 2 registered significantly greater 2,2 - diphenyl - 1 - picrylhydrazyl (DPPH) radical scavenging ability (IC50 < 0.65 mg / mL) than other analogues (IC50 ≥0.70 mg / mL). Ferrous ion (Fe2 + ) chelating ability was higher for 1–2 (IC50 ∼0.84 mg / mL) than α - tocopherol (IC50 0.89 mg / mL). The 5 - lipoxygenase inhibitory potential of furano - meroterpenoid analogue, 2 (IC50 0.76 mg / mL) was greater than other compounds (IC50 > 0.90 mg / mL). An optimum hydrophobic - hydrophilic balance of furano - meroterpenoid and lesser steric bulk manifested towards its greater bioactivities compared to other compounds. These anti - inflammatory and antioxidant leads could be used as potential functional food components. |
Description: | Not Available |
ISSN: | Not Available |
Type(s) of content: | Article |
Sponsors: | Not Available |
Language: | English |
Name of Journal: | Food Chemistry |
Volume No.: | 251 |
Page Number: | 125-134 |
Name of the Division/Regional Station: | Not Available |
Source, DOI or any other URL: | http://eprints.cmfri.org.in/12664/1/Minju Joy_Kajal Chakraborty_2018_Antioxidative and anti-inflammatory pyranoids and isochromenyl analogues from Corbiculid bivalve clam Villorita cyprinoides_Food Chemistry.pdf |
URI: | http://krishi.icar.gov.in/jspui/handle/123456789/64007 |
Appears in Collections: | FS-CMFRI-Publication |
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