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http://krishi.icar.gov.in/jspui/handle/123456789/68240| Title: | Effect of squalene on tissue defense system in isoproterenol-induced myocardial infarction in rats |
| Other Titles: | Not Available |
| Authors: | Sabeena Farvin, K.H. Anandan, R. HariSenthil Kumar, S. Shiny, K.S. Sankar, T. V. Thankappan, T.K. |
| ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
| Author's Affiliated institute: | ICAR::Central Institute of Fisheries Technology |
| Published/ Complete Date: | 2004-09 |
| Project Code: | Not Available |
| Keywords: | Squalene Myocardial infarction Diagnostic marker enzymes Lipid peroxidation Antioxidant enzymes |
| Publisher: | Elsevier |
| Citation: | Sabeena Farvin, K.H., Anandan, R., Hari Senthil Kumar, S., Shinu, K.S., Sankar, T.V., Thankappan, T.K. (2004). Effect of squaline on tissue defence system in isoprotonolol induced myocardial infraction in rats, Pharmacol Res., 50, 231-236. |
| Series/Report no.: | Not Available; |
| Abstract/Description: | This study was designed to examine the effects of squalene on tissue antioxidant status in isoproterenol - induced myocardial infarction in male albino rats. Levels of diagnostic marker enzymes [alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), and creatine phosphokinase (CPK)] in plasma, lipid peroxides, reduced glutathione, and the activities of glutathione - dependent antioxidant enzymes [glutathione peroxidase (GPx) and glutathione - S - transferase (GST)] and antiperoxidative enzymes [catalase (CAT) and superoxide dismutase (SOD)] in the heart tissue of experimental groups of rats were determined. The prior administration of squalene at 2% level along with feed for 45 days significantly prevented the isoproterenol - induced elevation in the levels of diagnostic marker enzymes in plasma of experimental rats. Squalene also exerted an antioxidant effect against isoproterenol - induced myocardial infarction by blocking the induction of lipid peroxidation. A tendency to prevent the isoproterenol - induced alterations in the level of reduced glutathione and in the activities of glutathione - dependent antioxidant enzymes and antiperoxidative enzymes was also observed. The cardioprotective effect of squalene might be ascribable to its antioxidant property and membrane stabilizing action. |
| Description: | Not Available |
| ISSN: | 1043-6618 |
| Type(s) of content: | Research Paper |
| Sponsors: | Not Available |
| Language: | English |
| Name of Journal: | Pharmacological Research |
| Journal Type: | International Journal |
| NAAS Rating: | 11.89 |
| Impact Factor: | 5.89 |
| Volume No.: | 50(3) |
| Page Number: | 231-236 |
| Name of the Division/Regional Station: | Not Available |
| Source, DOI or any other URL: | https://doi.org/10.1016/j.phrs.2004.03.004 |
| URI: | http://krishi.icar.gov.in/jspui/handle/123456789/68240 |
| Appears in Collections: | FS-CIFT-Publication |
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