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http://krishi.icar.gov.in/jspui/handle/123456789/72713
Title: | Functional and structural roles of the major facilitator superfamily bacterial multidrug efflux pumps. |
Other Titles: | Not Available |
Authors: | Kumar S, Lekshmi M, Parvathi A, Ojha M, Wenzel N, Varela MF* |
ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
Author's Affiliated institute: | ICAR: Central Institute of Fisheries Education |
Published/ Complete Date: | 2020-02-16 |
Project Code: | Not Available |
Keywords: | antimicrobial agents, multidrug resistance, bacteria, pathogens, major facilitator superfamily, transporters, sequence motifs, infection |
Publisher: | PMC PubMed Central |
Citation: | Not Available |
Series/Report no.: | Not Available; |
Abstract/Description: | Pathogenic microorganisms that are multidrug-resistant can pose severe clinical and public health concerns. In particular, bacterial multidrug efflux transporters of the major facilitator superfamily constitute a notable group of drug resistance mechanisms primarily because multidrug-resistant pathogens can become refractory to antimicrobial agents, thus resulting in potentially untreatable bacterial infections. The major facilitator superfamily is composed of thousands of solute transporters that are related in terms of their phylogenetic relationships, primary amino acid sequences, two- and three-dimensional structures, modes of energization (passive and secondary active), and in their mechanisms of solute and ion translocation across the membrane. The major facilitator superfamily is also composed of numerous families and sub-families of homologous transporters that are conserved across all living taxa, from bacteria to humans. Members of this superfamily share several classes of highly conserved amino acid sequence motifs that play essential mechanistic roles during transport. The structural and functional importance of multidrug efflux pumps that belong to the major facilitator family and that are harbored by Gram-negative and -positive bacterial pathogens are considered here. |
Description: | Not Available |
ISSN: | Not Available |
Type(s) of content: | Research Paper |
Sponsors: | Not Available |
Language: | English |
Name of Journal: | Microorganisms |
Journal Type: | International |
NAAS Rating: | 10.15 |
Impact Factor: | 3.86 |
Volume No.: | 8(2) |
Page Number: | 266 |
Name of the Division/Regional Station: | Not Available |
Source, DOI or any other URL: | Not Available |
URI: | http://krishi.icar.gov.in/jspui/handle/123456789/72713 |
Appears in Collections: | FS-CIFE-Publication |
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