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http://krishi.icar.gov.in/jspui/handle/123456789/73011| Title: | Biomarkers for assessing chronic toxicity of carbamazepine, an anticonvulsants drug on Pangasianodon hypophthalmus (Sauvage, 1878). |
| Other Titles: | Not Available |
| Authors: | Droma D, Kumar S, Paul T, Pal P, Saharan N, Kumar K, Poojary N |
| ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
| Author's Affiliated institute: | ICAR: Central Institute of Fisheries Education |
| Published/ Complete Date: | 2021-10-01 |
| Project Code: | Not Available |
| Keywords: | Carbamazepine Integrated biomarker response Oxidative stress MicronucleusP. hypophthalmus |
| Publisher: | ELSEVIER |
| Citation: | Not Available |
| Series/Report no.: | Not Available; |
| Abstract/Description: | In recent times, carbamazepine (CBZ) as an anticonvulsants drug has raised attention because of its safety concern in the aquatic environment. The present study aimed to evaluate the sub-lethal effects of CBZ (1%, 0.1 % and 0.01 % of 96 h LC50) on P. hypophthalmus for 60 days based on haematological, biochemical, and genotoxicity biomarkers. Chronic exposure of CBZ altered blood profiles (total erythrocyte count, packed cell volume, haemoglobin) and serum biomarkers such as alkaline phosphates, cholesterol, lactate dehydrogenase and transaminase enzymes. Oxidative stress biomarkers such as superoxide dismutase (SOD) and catalase (CAT) activity were also substantially affected in all treatments. Genotoxicity study revealed the formation of micronucleus in erythrocytes of exposed fish. Integrated Biomarker Response (IBR) study showed cholesterol, serum glutamic oxaloacetic transaminase (SGOT) in serum and SOD, CAT in liver tissue are the best organ-based enzyme biomarkers. The present report concludes that an environmentally realistic concentration of CBZ can pose a serious threat to aquatic organisms. |
| Description: | Not Available |
| ISSN: | Not Available |
| Type(s) of content: | Research Paper |
| Sponsors: | Not Available |
| Language: | English |
| Name of Journal: | Environmental Toxicology and Pharmacology |
| Journal Type: | International |
| NAAS Rating: | 10.86 |
| Impact Factor: | 4.86 |
| Volume No.: | 87 |
| Page Number: | 103691 |
| Name of the Division/Regional Station: | Not Available |
| Source, DOI or any other URL: | Not Available |
| URI: | http://krishi.icar.gov.in/jspui/handle/123456789/73011 |
| Appears in Collections: | FS-CIFE-Publication |
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