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http://krishi.icar.gov.in/jspui/handle/123456789/74275| Title: | Protective effect of taurine on myocardial antioxidant status in isoprenaline-induced myocardial infarction in rats |
| Other Titles: | Not Available |
| Authors: | Shiny, K. S. Senthil Kumar, S. H. Farvin, K. H. S. Anandan, R. Devadasan, K. |
| ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
| Author's Affiliated institute: | ICAR::Central Institute of Fisheries Technology |
| Published/ Complete Date: | 2005-10 |
| Project Code: | Not Available |
| Keywords: | Not Available |
| Publisher: | Wiley |
| Citation: | Shiny, K. S., Senthil Kumar, S. H., Farvin, K. H. S., Anandan, R. and Devadasan, K. (2005) Protective effect of taurine on myocardial antioxidant status in isoprenaline-induced myocardial infarction in rats. |
| Series/Report no.: | Not Available; |
| Abstract/Description: | We have examined the protective effect of taurine on the myocardial antioxidant defense system in isoprenaline (isoproterenol)-induced myocardial infarction in rats, an animal model of myocardial infarction in man. Levels of diagnostic marker enzymes in plasma, lipid peroxides and reduced glutathione, and the activity of glutathione-dependent antioxidant enzymes and antiperoxidative enzymes in the heart tissue were determined. Intraperitoneal administration of taurine significantly prevented the isoprenaline-induced increases in the levels of alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, and creatine phosphokinase in the plasma of rats. Taurine exerted an antioxidant effect against isoprenaline-induced myocardial infarction by preventing the accumulation of lipid peroxides and by maintaining the level of reduced glutathione and the activity of glutathione peroxidase, glutathione-S-transferase, catalase and superoxide dismutase at near normality. The results indicated that the cardioprotective potential of taurine was probably due to the increase of the activity of the free radical enzymes, or to a counteraction of free radicals by its antioxidant nature, or to a strengthening of myocardial membrane by its membrane stabilizing property. |
| Description: | Not Available |
| ISSN: | 0022-3573 |
| Type(s) of content: | Research Paper |
| Sponsors: | Not Available |
| Language: | English |
| Name of Journal: | Journal of Pharmacy and Pharmacology |
| Journal Type: | International |
| NAAS Rating: | 9.77 |
| Impact Factor: | 3.77 |
| Volume No.: | 57(10) |
| Page Number: | 1313-1317 |
| Name of the Division/Regional Station: | Biochemistry and Nutrition Division |
| Source, DOI or any other URL: | https://doi.org/10.1211/jpp.57.10.0010 |
| URI: | http://krishi.icar.gov.in/jspui/handle/123456789/74275 |
| Appears in Collections: | FS-CIFT-Publication |
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