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http://krishi.icar.gov.in/jspui/handle/123456789/83366| Title: | Anti-ulcerogenic effect of chitin and chitosan on mucosal antioxidant defence system in HCl ethanol induced ulcer in rats |
| Other Titles: | Not Available |
| Authors: | Anandan, R. Suseela Mathew Viswanathan Nair, P. G. |
| ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
| Author's Affiliated institute: | ICAR::Central Institute of Fisheries Technology |
| Published/ Complete Date: | 2004-02 |
| Project Code: | Not Available |
| Keywords: | Not Available |
| Publisher: | Wiley |
| Citation: | Anandan, R., Suseela Mathew and Viswanathan Nair, P. G. (2004) Anti-ulcerogenic effect of chitin and chitosan on mucosal antioxidant defence system in HCl ethanol induced ulcer in rats. J. Pharm. Pharmacol. 56(2):265-269. |
| Series/Report no.: | Not Available; |
| Abstract/Description: | The anti-ulcerogenic effect of chitin and chitosan against ulcer induced by HCl–ethanol in male Wistar rats was studied. Levels of acid output, pepsin, protein, lipid peroxides and reduced glutathione and the activity of glutathione peroxidase (GPx), glutathione-S-transferase (GST), catalase (CAT) and super oxide dismutase (SOD) were determined in the gastric mucosa of normal and experimental groups of rats. A significant increase in volume and acidity of the gastric juice was observed in the ulcer-induced group of rats. Peptic activity was significantly decreased as compared with that of normal controls. In the rats pre-treated with chitin and chitosan 2% along with feed, the volume and acid output and peptic activity of gastric mucosa were maintained at near normal levels. The level of lipid peroxidation was significantly higher in the ulcerated mucosa when compared with that of normal controls. This was paralleled by a decline in the level of reduced glutathione and in the activity of antioxidant enzymes like GPx, GST, CAT and SOD in the gastric mucosa of ulcer-induced rats. Also, the levels of mucosal proteins and glycoprotein components were significantly depleted in ulcerated mucosa. The pre-treatment with chitin and chitosan was found to exert a significant anti-ulcer effect by preventing all the HCl-ethanol-induced ulcerogenic effects in experimental rats. |
| Description: | Not Available |
| ISSN: | 0022-3573 |
| Type(s) of content: | Research Paper |
| Sponsors: | Not Available |
| Language: | English |
| Name of Journal: | Journal of Pharmacy and Pharmacology |
| Journal Type: | International |
| Volume No.: | 56(2) |
| Page Number: | 265-269 |
| Name of the Division/Regional Station: | Not Available |
| Source, DOI or any other URL: | https://doi.org/10.1211/0022357023079 |
| URI: | http://krishi.icar.gov.in/jspui/handle/123456789/83366 |
| Appears in Collections: | FS-CIFT-Publication |
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