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http://krishi.icar.gov.in/jspui/handle/123456789/35394| Title: | Effect of Methotrexate Induced Oxidative Stress in The Liver of Wistar Albino Rats |
| Other Titles: | Not Available |
| Authors: | Akshata SA Rao S Satyanarayana ML Narayanaswamy HD Byregowda SM Reddy GBM |
| ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
| Author's Affiliated institute: | Department of Veterinary Pathology, Veterinary College, KVAFSU, Hebbal, Bengaluru - 560 024 KVAFSU, Bidar - 585 401 IAH & VB, Bellary Rd, Vinayakanagar, Sanjaynagar, Bengaluru - 560 024 ICAR::National Institute of Veterinary Epidemiology and Disease Informatics |
| Published/ Complete Date: | 2019-08-02 |
| Project Code: | Not Available |
| Keywords: | Methotrexate oxidative stress endogenous anti oxidant enzymes |
| Publisher: | International Journal of Science Environment and Technology |
| Citation: | Not Available |
| Series/Report no.: | Not Available; |
| Abstract/Description: | The present study was conducted to assess methotrexate (MTX) induced toxicity in Wistar male albino rats. The study had two groups with 12 rats in each. MTX was used at the dose of 5mg/kg b.w. to induce toxicity. In MTX control group the levels of endogenous antioxidant enzymes such as SOD, CAT and GPx were significantly reduced compared to those of normal control. The MDA levels caused by lipid peroxidation as a result of oxidant injury to liver was significantly higher in MTX positive controlthan compared to that of normal control. In conclusion MTX induces hepatotoxicity in rats through oxidative stress evidenced by decreased levels of endogenous antioxidant enzymes such as SOD, CAT and GPx and increased levels of MDA indicating increased extent of oxidative injury caused by MTX on hepatocytes. |
| Description: | Not Available |
| ISSN: | 2278-3687 |
| Type(s) of content: | Research Paper |
| Sponsors: | Not Available |
| Language: | English |
| Name of Journal: | International Journal of Science, Environment and Technology |
| Volume No.: | 8(4) |
| Page Number: | 840-844 |
| Name of the Division/Regional Station: | Not Available |
| Source, DOI or any other URL: | http://www.ijset.net/journal/2397.pdf |
| URI: | http://krishi.icar.gov.in/jspui/handle/123456789/35394 |
| Appears in Collections: | AS-NIVEDI-Publication |
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