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Please use this identifier to cite or link to this item:
http://krishi.icar.gov.in/jspui/handle/123456789/4974
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | C.D. Nwani | en_US |
dc.contributor.author | W.S. Lakra | en_US |
dc.contributor.author | N.S. Nagpure | en_US |
dc.contributor.author | Ravindra Kumar | en_US |
dc.contributor.author | B. Kushwaha | en_US |
dc.contributor.author | S.K. Srivastava | en_US |
dc.date.accessioned | 2017-07-25T08:46:15Z | - |
dc.date.available | 2017-07-25T08:46:15Z | - |
dc.date.issued | 2010-01 | - |
dc.identifier.citation | Nwani, C.D., Lakra, W.S., Nagpure, N.S., Kumar, R., Kushwaha, B. and Srivastava, S.K., 2010. Mutagenic and genotoxic effects of carbosulfan in freshwater fish Channa punctatus (Bloch) using micronucleus assay and alkaline single-cell gel electrophoresis. Food and Chemical Toxicology, 48(1), pp.202-208. | en_US |
dc.identifier.other | Not Available | - |
dc.identifier.uri | http://krishi.icar.gov.in/jspui/handle/123456789/4974 | - |
dc.description | Not Available | en_US |
dc.description.abstract | Carbosulfan insecticide is widely used in agriculture and was recently proposed for treatment against pyrethroid-resistant mosquitoes. The mutagenic and genotoxic effect of carbosulfan was carried out in fish Channa punctatus using micronucleus (MN) test and comet assay. The 96 h LC50, estimated by probit analysis in a semi-static bioassay experiment, was 0.268 mg l1 Based on the LC50 value, three sub-lethal concentrations of carbosulfan (1/4th LC50 = 67 lg l1 1/2nd LC50 = 134 lg l1 and 3/4thLC50 = 201 lg l1 ) were selected and fishes were exposed to the said concentrations for 96 h and the samplings were done at regular intervals of 24 h for assessment of the MN frequencies and DNA damage. In general, significant effects (P < 0.01) from both concentrations and time of exposure were observed in exposed fishes. The MN induction was highest on 96 h at all the concentrations in the peripheral blood. Similar trend was observed for the DNA damage measured in terms of the percentage of tail DNA in the erythrocyte and gill cells. This study confirmed that the comet and micronucleus assays are useful tools in determining potential genotoxicity of water pollutants and might be appropriate as a part of monitoring program. | en_US |
dc.description.sponsorship | Academy of Science for Developing World (TWAS) | en_US |
dc.description.sponsorship | Department of Biotechnology, Government of India (DBT) | en_US |
dc.language.iso | English | en_US |
dc.publisher | ELSEVIER | en_US |
dc.relation.ispartofseries | Not Available; | - |
dc.subject | Carbosulfan | en_US |
dc.subject | Channa punctatus | en_US |
dc.subject | Comet assay | en_US |
dc.subject | DNA damage | en_US |
dc.subject | Genotoxicity | en_US |
dc.subject | Micronucleus | en_US |
dc.title | Mutagenic and genotoxic effects of carbosulfan in freshwater fish Channa punctatus (Bloch) using micronucleus assay and alkaline single-cell gel electrophoresis | en_US |
dc.title.alternative | Not Available | en_US |
dc.type | Research Paper | en_US |
dc.publication.projectcode | Not Available | en_US |
dc.publication.journalname | Food and Chemical Toxicology | en_US |
dc.publication.volumeno | 48 | en_US |
dc.publication.pagenumber | 202–208 | en_US |
dc.publication.divisionUnit | Not Available | en_US |
dc.publication.sourceUrl | 10.1016/j.fct.2009.09.041 | en_US |
dc.publication.naasrating | 10.68 | en_US |
Appears in Collections: | FS-NBFGR-Publication |
Files in This Item:
File | Description | Size | Format | |
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1-s2.0-S0278691509004499-main.pdf | 373.29 kB | Adobe PDF | View/Open |
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