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http://krishi.icar.gov.in/jspui/handle/123456789/52886
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | S. Kumar | en_US |
dc.contributor.author | T. Paul | en_US |
dc.contributor.author | S.P. Shukla | en_US |
dc.contributor.author | K. Kumar | en_US |
dc.contributor.author | S. Karmakar | en_US |
dc.contributor.author | K. K. Bera | en_US |
dc.contributor.author | C. B. Kumar | en_US |
dc.date.accessioned | 2021-08-04T07:41:27Z | - |
dc.date.available | 2021-08-04T07:41:27Z | - |
dc.date.issued | 2021-10-01 | - |
dc.identifier.citation | Saurav Kumar, Tapas Paul, S.P. Shukla, Kundan Kumar, Sutanu Karmakar, Kuntal Krishna Bera, Chandra Bhushan kumar, Biomarkers-based assessment of triclosan toxicity in aquatic environment: A mechanistic review, Environmental Pollution, Volume 286, 2021, 117569, ISSN 0269-7491, https://doi.org/10.1016/j.envpol.2021.117569 | en_US |
dc.identifier.issn | 0269-7491 | - |
dc.identifier.uri | http://krishi.icar.gov.in/jspui/handle/123456789/52886 | - |
dc.description | Not Available | en_US |
dc.description.abstract | Triclosan (TCS), an emergent pollutant, is raising a global concern due to its toxic effects on organisms and aquatic ecosystems. The non-availability of proven treatment technologies for TCS remediation is the central issue stressing thorough research on understanding the underlying mechanisms of toxicity and assessing vital biomarkers in the aquatic organism for practical monitoring purposes. Given the unprecedented circumstances during COVID 19 pandemic, a several-fold higher discharge of TCS in the aquatic ecosystems cannot be considered a remote possibility. Therefore, identifying potential biomarkers for assessing chronic effects of TCS are prerequisites for addressing the issues related to its ecological impact and its monitoring in the future. It is the first holistic review on highlighting the biomarkers of TCS toxicity based on a comprehensive review of available literature about the biomarkers related to cytotoxicity, genotoxicity, hematological, alterations of gene expression, and metabolic profiling. This review establishes that biomarkers at the subcellular level such as oxidative stress, lipid peroxidation, neurotoxicity, and metabolic enzymes can be used to evaluate the cytotoxic effect of TCS in future investigations. Micronuclei frequency and % DNA damage proved to be reliable biomarkers for genotoxic effects of TCS in fishes and other aquatic organisms. Alteration of gene expression and metabolic profiling in different organs provides a better insight into mechanisms underlying the biocide's toxicity. In the concluding part of the review, the present status of knowledge about mechanisms of antimicrobial resistance of TCS and its relevance in understanding the toxicity is also discussed referring to the relevant reports on microorganisms. | en_US |
dc.description.sponsorship | Not Available | en_US |
dc.language.iso | English | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.ispartofseries | Not Available; | - |
dc.subject | Triclosan | en_US |
dc.subject | Biomarker | en_US |
dc.subject | Genotoxicity | en_US |
dc.subject | Endocrine disruption | en_US |
dc.subject | Antimicrobial resistance | en_US |
dc.title | Biomarkers-based assessment of triclosan toxicity in aquatic environment: A mechanistic review | en_US |
dc.title.alternative | Not Available | en_US |
dc.type | Research Paper | en_US |
dc.publication.projectcode | Not Available | en_US |
dc.publication.journalname | Environmental Pollution | en_US |
dc.publication.volumeno | 286 | en_US |
dc.publication.pagenumber | 117569 | en_US |
dc.publication.divisionUnit | Fish Health Management and Exotics | en_US |
dc.publication.sourceUrl | https://doi.org/10.1016/j.envpol.2021.117569 | en_US |
dc.publication.sourceUrl | https://www.sciencedirect.com/science/article/pii/S0269749121011519 | en_US |
dc.publication.authorAffiliation | ICAR-Central Institute of Fisheries Education, Mumbai, Maharashtra | en_US |
dc.publication.authorAffiliation | West Bengal University of Animal & Fishery Sciences, Kolkata, West Bengal | en_US |
dc.publication.authorAffiliation | ICAR-National Bureau of Fish Genetic Resources, Lucknow, Uttar Pradesh | en_US |
dc.ICARdataUseLicence | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf | en_US |
dc.publication.journaltype | Environmental Pollution is an international peer-reviewed journal that publishes high quality research papers and review articles about all aspects of environmental pollution and its effects on ecosystems and human health. The journal welcomes high-quality process-oriented and hypothesis-based submissions that report results from original and novel research and contribute new knowledge to help address problems related to environmental pollution at a regional or global scale. | en_US |
dc.publication.naasrating | 12.79 | en_US |
dc.publication.impactfactor | 8.071 | en_US |
Appears in Collections: | FS-NBFGR-Publication |
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