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http://krishi.icar.gov.in/jspui/handle/123456789/62005| Title: | PIR pairwise alignment - a slip up for signal peptides |
| Other Titles: | Not Available |
| Authors: | S Baiaji R Kalpana Eapen S J |
| ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
| Author's Affiliated institute: | ICAR::Indian Institute of Spices Research |
| Published/ Complete Date: | 2006-08-14 |
| Project Code: | Not Available |
| Keywords: | PIR pairwise alignment signal peptides |
| Publisher: | ICAR- Indian institute of spices research,Kozhikode, Kerala India |
| Citation: | Balaji S, Kalpana R, Eapen SJ. PIR pairwise alignment - a slip up for signal peptides. Bioinformation. 2006 Aug 14;1(5):188-93. doi: 10.6026/97320630001188. PMID: 17597886; PMCID: PMC1891675. |
| Series/Report no.: | Not Available; |
| Abstract/Description: | The ability to calculate the correct sequence alignment is crucial to many types of studies. The accuracy in alignment is critical in predicting gene ancestry, the number and location of point mutations, evolutionary distance and phylogeny. A study was conducted to test the biological significance of PIR pairwise alignment using 40 N-terminal signal peptides of different taxonomic origin and having various functions. Our results suggest that PIR pairwise alignment is not ideal for some proteins with N-terminal signal peptides, because it produces an erroneous alignment that lacks both statistical and biological significances. This communication discusses the shortcomings in the PIR pairwise alignment tool and calls for a cautious approach while using it for signal peptides. |
| Description: | Not Available |
| ISSN: | Not Available |
| Type(s) of content: | Research Paper |
| Sponsors: | Not Available |
| Language: | English |
| Name of Journal: | Bioinformation |
| Volume No.: | 1(5) |
| Page Number: | 188-93 |
| Name of the Division/Regional Station: | Not Available |
| Source, DOI or any other URL: | https://doi.org/10.6026/97320630001188 |
| URI: | http://krishi.icar.gov.in/jspui/handle/123456789/62005 |
| Appears in Collections: | HS-IISR-Publication |
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