KRISHI
ICAR RESEARCH DATA REPOSITORY FOR KNOWLEDGE MANAGEMENT
(An Institutional Publication and Data Inventory Repository)
"Not Available": Please do not remove the default option "Not Available" for the fields where metadata information is not available
"1001-01-01": Date not available or not applicable for filling metadata infromation
"1001-01-01": Date not available or not applicable for filling metadata infromation
Please use this identifier to cite or link to this item:
http://krishi.icar.gov.in/jspui/handle/123456789/63771
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Thilakan,Bini | - |
dc.contributor.author | Raola,Vamshi Krishna | - |
dc.contributor.author | Chakraborty,Kajal | - |
dc.date.accessioned | 2021-09-17T07:57:25Z | - |
dc.date.available | 2021-09-17T07:57:25Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Not Available | - |
dc.identifier.issn | Not Available | - |
dc.identifier.uri | http://krishi.icar.gov.in/jspui/handle/123456789/63771 | - |
dc.description | Not Available | en_US |
dc.description.abstract | Brown seaweed Anthophycus longifolius (Turner) Kützing (family Sargassaceae) associated heterotrophic bacterium Bacillus subtilis MTCC 10403 was found to be a potent isolate with broad range of antibacterial activity against important perceptive food pathogens Vibrio parahaemolyticus, V. vulnificus, and Aeromonas hydrophila. This bacterium was positive for polyketide synthetase gene (KC589397), and therefore, was selected to bioprospect specialized metabolites bearing polyketide backbone. Bioactivity-guided chromatographic fractionation of the ethyl acetate extract of the seaweed-associated bacterium segregated four homologous polyketide furanoterpenoids with potential antibacterial activities against clinically important pathogens. The minimum inhibitory concentration (MIC) assay showed that the referral antibiotics tetracycline and ampicillin were active at 25 mg/mL against the test pathogens, whereas the previously undescribed (4E)-methyl 13-((16-(furan-2-yl) ethyl)-octahydro-7-hydroxy-4-((E)-23- methylbut-21-enyl)-2H-chromen-6-yl)-4-methylpent-4-enoate (compound 1) and methyl 3-(hexahydro- 9-((E)-3-methylpent-1-enyl)-4H-furo[3,2-g]isochromen-6-yl) propanoate (compound 3) displayed antibacterial activities against the test pathogens at a lesser concentration (MIC < 7 mg/mL). The title compounds were characterized by comprehensive nuclear magnetic resonance and mass spectroscopic experiments. Polyketide synthase catalyzed putative biosynthetic mechanism additionally corroborated the structural ascriptions of the hitherto undescribed furanoterpenoids from seaweed-associated bacterial symbiont. The electronic and hydrophobic parameters appeared to hold a conspicuous part in directing the antibacterial properties of the compounds. Seaweed-associated B. subtilis MTCC 10403 demonstrated to represent a potential source of antimicrobial polyketides for pharmaceutical applications. | en_US] |
dc.description.sponsorship | Not Available | - |
dc.language.iso | English | - |
dc.publisher | Not Available | en_US |
dc.relation.ispartofseries | Not Available | - |
dc.subject | Anthophycus longifolius | en_US |
dc.subject | Sargassaceae | en_US |
dc.subject | Seaweed | en_US |
dc.subject | Bacillus subtilis MTCC 10403 | en_US |
dc.subject | Antibacterial activity | en_US |
dc.subject | Polyketide furanoterpenoids | en_US |
dc.subject | Polyketide synthase | en_US |
dc.title | Antimicrobial polyketide furanoterpenoids from seaweed-associated heterotrophic bacterium Bacillus subtilis MTCC 10403 | en_US |
dc.title.alternative | Not Available | - |
dc.type | Article | en_US |
dc.publication.projectcode | Not Available | - |
dc.publication.journalname | Phytochemistry | - |
dc.publication.volumeno | 142 | - |
dc.publication.pagenumber | 112-125 | - |
dc.publication.divisionUnit | Not Available | - |
dc.publication.sourceUrl | http://www.sciencedirect.com/science/article/pii/S0031942217302492 | - |
dc.publication.sourceUrl | eprints.cmfri.org.in/11992/1/Kajal Chakraborty_2017_Phytochemistry_Antimicrobial polyketide furanoterpenoids from seaweed-associated heterotrophic bacterium.pdf | - |
dc.publication.authorAffiliation | Not Available | - |
dc.ICARdataUseLicence | Not Available | en_US |
dc.publication.submitter | krishi.admin2@icar.gov.in | - |
Appears in Collections: | FS-CMFRI-Publication |
Files in This Item:
There are no files associated with this item.
Items in KRISHI are protected by copyright, with all rights reserved, unless otherwise indicated.