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Please use this identifier to cite or link to this item:
http://krishi.icar.gov.in/jspui/handle/123456789/63990
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Raola,Vamshi Krishna | - |
dc.contributor.author | Chakraborty,Kajal | - |
dc.date.accessioned | 2021-09-17T09:00:26Z | - |
dc.date.available | 2021-09-17T09:00:26Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Not Available | - |
dc.identifier.issn | Not Available | - |
dc.identifier.uri | http://krishi.icar.gov.in/jspui/handle/123456789/63990 | - |
dc.description | Not Available | en_US |
dc.description.abstract | Two oleanenes, olean-18(19)-en-3b-yl-(3,6-dimethyl-3E,6Z-dienoate) and (13a)-27-frido-olean-14(15)- en-(17a)-furanyl-3b-ol representing a class of rare natural pentacyclic triterpenoids were isolated from the chloroform extract of Asiatic mangrove, Rhizophora mucronata Lam. (Family: Rhizophoraceae). The furanyl oleanene exhibited significantly greater antioxidative activities (IC50 0.73e0.76 mg/mL), than prenylated oleanene (IC50 0.84e0.96 mg/mL) (P < 0.05). No significant differences in anti-5-lipoxygenase activities of these compounds with the synthetic drug ibuprofen was discernable (IC50 0.8e0.9 mg/mL), whilst furanyl oleanene demonstrated significantly greater anti-cyclooxygenase-2 (IC50 0.84 mg/mL) and anti-5-lipoxygenase activities (IC50 0.78 mg/mL) over prenylated oleanene (IC50 > 0.90 mg/mL). These compounds exhibited lesser activity against cyclooxygenase-1 than cyclooxygenase-2 isoform, and therefore, their selectivity indices remained significantly greater (anti-cyclooxygenase-1IC50/anti-cyclooxygenase- 2IC50 > 1) than the aspirin (0.02) and ibuprofen (0.44). The lipophilic and steric molecular descriptors were found to occupy a prominent role in determining the bioactivities of the compounds. These previously undescribed oleanenes might serve as potential antioxidative and anti-inflammatory lead molecules in medicinal formulations and food industries. | en_US] |
dc.description.sponsorship | Not Available | - |
dc.language.iso | English | - |
dc.publisher | Not Available | en_US |
dc.relation.ispartofseries | Not Available | - |
dc.subject | Rhizophora mucronata Lam. | en_US |
dc.subject | Rhizophoraceae | en_US |
dc.subject | Olean-18(19)-en-3β-yl (3, 6-dimethyl-3, 6-dienoate) | en_US |
dc.subject | (13α) 27-Frido-olean-14(15)-en-(17α)-furanyl-3β-ol | en_US |
dc.subject | Antioxidative | en_US |
dc.subject | Cyclooxygenase-2 | en_US |
dc.subject | 5-Lipoxygenase | en_US |
dc.subject | Structure activity relationship analysis | en_US |
dc.title | Two rare antioxidant and anti-inflammatory oleanenes from loop root Asiatic mangrove Rhizophora mucronata | en_US |
dc.title.alternative | Not Available | - |
dc.type | Article | en_US |
dc.publication.projectcode | Not Available | - |
dc.publication.journalname | Phytochemistry | - |
dc.publication.volumeno | 135 | - |
dc.publication.pagenumber | 160-168 | - |
dc.publication.divisionUnit | Not Available | - |
dc.publication.sourceUrl | http://www.sciencedirect.com/science/article/pii/S0031942216302977 | - |
dc.publication.sourceUrl | http://eprints.cmfri.org.in/10791/1/Phytochemistry_Rare oleanenes from Rhizophora_Kajal Chakraborty_2017.pdf | - |
dc.publication.authorAffiliation | Not Available | - |
dc.ICARdataUseLicence | Not Available | en_US |
dc.publication.submitter | krishi.admin2@icar.gov.in | - |
Appears in Collections: | FS-CMFRI-Publication |
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