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Please use this identifier to cite or link to this item:
http://krishi.icar.gov.in/jspui/handle/123456789/64005
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chakraborty,Kajal | - |
dc.contributor.author | Salas,Soumya | - |
dc.date.accessioned | 2021-09-17T09:00:28Z | - |
dc.date.available | 2021-09-17T09:00:28Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Not Available | - |
dc.identifier.issn | Not Available | - |
dc.identifier.uri | http://krishi.icar.gov.in/jspui/handle/123456789/64005 | - |
dc.description | Not Available | en_US |
dc.description.abstract | A 16-member polyether macrocyclic lactone, with previously unreported framework was isolated as a result of the bioassay guided chromatographic fractionation of the ethyl acetate-methanol extract of the Babylonidae Babylonia spirata collected from the southwestern coast of Indian peninsular. The compound was characterized as 10, 14-dihydroxy-4-(1′-propyl-1′(Z)-hexen-1′-yl)-7, 12-dioxapentadecanolide based on extensive spectral data analysis. The antioxidant activities evaluated by in vitro free radical scavenging capacities reported that the studied compound possessed greater activity (IC50 0.058–0.065 × 10−2 M) than the commercial standards, butylated hydroxy anisole, butylated hydroxyl toluene and α-tocopherol (IC50 0.118–0.189 × 10−2 M). The compound was found to possess greater anti-inflammatory potentials as recognized by its lower IC50 value for the 5-lipoxygenase inhibition assay (0.073 × 10−2 M) than the non steroidal anti-inflammatory drugs aspirin (0.211 × 10−2 M) and ibuprofen (0.436 × 10−2 M). Structure-activity studies showed that bioactivities of the polyether macrocyclic lactone were directed by electronic and lipophilic descriptors. The lipophilic parameter of octanol-water partition coefficient (log Pow) of the studied compound recorded a value as low as 2.76 when judged against commercial antioxidant α-tocopherol (log Pow 9.98), and was recognized as a primary physico-chemical descriptor dictating the antioxidant characteristics of the isolated polyether macrocyclic lactone, whereas the electronic parameters appeared to contribute towards its anti-inflammatory activity. This is the first report of the occurrence of macrocyclic lactone featuring a dioxapentadecanolide framework possessing potential antioxidative and anti-inflammatory activities, and therefore, anticipated as a potential naturally-derived antioxidative and anti-inflammatory constituent in functional food and pharmaceutical applications. | en_US] |
dc.description.sponsorship | Not Available | - |
dc.language.iso | English | - |
dc.publisher | Not Available | en_US |
dc.relation.ispartofseries | Not Available | - |
dc.subject | Gastropod mollusc | en_US |
dc.subject | Buccinidae | en_US |
dc.subject | Babylonia spirata | en_US |
dc.subject | Polyether | en_US |
dc.subject | macrocyclic Lactone | en_US |
dc.subject | Antioxidant | en_US |
dc.subject | Anti-inflammatory | en_US |
dc.title | An unreported polyether macrocyclic lactone with antioxidative and anti-lipoxygenase activities from the Babylonidae gastropod mollusc Babylonia spirata | en_US |
dc.title.alternative | Not Available | - |
dc.type | Article | en_US |
dc.publication.projectcode | Not Available | - |
dc.publication.journalname | Medicinal Chemistry Research | - |
dc.publication.volumeno | 27 | - |
dc.publication.pagenumber | 2446-2453 | - |
dc.publication.divisionUnit | Not Available | - |
dc.publication.sourceUrl | https://link.springer.com/article/10.1007%2Fs00044-018-2248-z | - |
dc.publication.sourceUrl | http://eprints.cmfri.org.in/13242/1/Kajal Chakraborty_2018_Medicinal Chemistry Research_Unreported polyether macrocyclic lactone from Babylonia spirata.pdf | - |
dc.publication.authorAffiliation | Not Available | - |
dc.ICARdataUseLicence | Not Available | en_US |
dc.publication.submitter | krishi.admin2@icar.gov.in | - |
Appears in Collections: | FS-CMFRI-Publication |
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