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http://krishi.icar.gov.in/jspui/handle/123456789/72643
Title: | Responses of some innate immune‐genes involved in the toll‐pathway in black tiger shrimp (Penaeus monodon) to Vibrio harveyi infection and on exposure to ligands in vitro. |
Other Titles: | Not Available |
Authors: | Deepika A, Sreedharan K, Rajendran KV |
ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
Author's Affiliated institute: | ICAR: Central Institute of Fisheries Education |
Published/ Complete Date: | 2020-04-21 |
Project Code: | Not Available |
Keywords: | ligands, penaeus monodon, toll-pathway, vibrio harveyi |
Publisher: | WILEY |
Citation: | Not Available |
Series/Report no.: | Not Available; |
Abstract/Description: | In shrimp, which rely largely on their innate immune systemfor defense against invading pathogens, the Toll-pathwayhas been extensively studied, as it plays a crucial role ininnate immune responses. Different innate immune genesin the Toll-pathway of shrimp,Penaeus monodonviz., Toll-Like receptor (PmToll), Myeloid differentiation factor-88(PmMyD88), and Tumor necrosis factor receptor associatedfactor-6 (PmTRAF6) have been characterized and their rolein immune response against white spot syndrome virus hasbeen elucidated by real-time PCR-based expression analy-sis. In the current study, the role of these genes in theimmune response against bacteria was investigated bydetermining the mRNA expressions ofPmToll,PmMyD88,andPmTRAF6 in different tissues ofP. monodon, uponexperimental infection withVibrio harveyi, using real-timePCR. Seven tissues were selected, including hemocytes,lymphoid organ, gill, hepatopancreas, stomach, midgut, andhindgut. Significant upregulation of these genes wasobserved in hemocytes, lymphoid organ, and gut tissues atdifferent time-points after infection. Moreover, modulationof expression of the genes at different time-points could beobserved in primary cultured hemocytes in vitro upon expo-sure with pathogen-mimicking ligands (lipopolysacchridesand peptidoglycans). These experimental results indicate that the Toll-pathway plays an important role in the immune response against bacterial challenge. |
Description: | Not Available |
ISSN: | Not Available |
Type(s) of content: | Research Paper |
Sponsors: | Not Available |
Language: | English |
Name of Journal: | Journal of the World Aquaculture Society |
Journal Type: | International |
NAAS Rating: | 7.45 |
Impact Factor: | 2.516 |
Volume No.: | 51(6) |
Page Number: | 1419-29 |
Name of the Division/Regional Station: | Not Available |
Source, DOI or any other URL: | Not Available |
URI: | http://krishi.icar.gov.in/jspui/handle/123456789/72643 |
Appears in Collections: | FS-CIFE-Publication |
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