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http://krishi.icar.gov.in/jspui/handle/123456789/74620Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Anju Manuja, Balvinder Kumar, Meenu Chopra, Anshu Bajaj, Rajender Kumara, Neeraj Dilbaghi, Sandeep Kumar, Sandeep Singh, T. Riyesh, Suresh C. Yadav | en_US |
| dc.date.accessioned | 2022-09-29T09:49:29Z | - |
| dc.date.available | 2022-09-29T09:49:29Z | - |
| dc.date.issued | 2016-03-18 | - |
| dc.identifier.citation | Not Available | en_US |
| dc.identifier.issn | Not Available | - |
| dc.identifier.uri | http://krishi.icar.gov.in/jspui/handle/123456789/74620 | - |
| dc.description | Not Available | en_US |
| dc.description.abstract | We synthesized quinapyramine sulfate loaded-sodium alginate nanoparticles (QS-NPs) to reduce unde-sirable toxic effects of QS against the parasite Trypanosoma evansi, a causative agent of trypanosomosis. To determine the safety of the formulated nanoparticles, biocompatibility of QS-NPs was determined using Vero, Hela cell lines and horse erythrocytes in a dose-dependent manner. Our experiments unveiled a concentration-dependent safety/cytotoxicity (metabolic activity), genotoxicity (DNA damage, chromosomal aberrations), production of reactive oxygen species and hemolysis in QS-NPs treated cells. Annexin-Vpropidium iodide (PI) staining showed no massive apoptosis or necrosis. However, at very high doses(more than 300 times than the effective doses), we observed more toxicity in QS-NPs treated cells as compared to QS treated cells. QS-NPs were safe at effective trypanocidal doses and even at doses several times higher than the effective dose. | en_US |
| dc.description.sponsorship | Not Available | en_US |
| dc.language.iso | English | en_US |
| dc.publisher | Elsevier | en_US |
| dc.relation.ispartofseries | Not Available; | - |
| dc.subject | Trypanosoma; Nanomedicine; Genotoxicity; Cytotoxicity; Oxidative stress | en_US |
| dc.title | Cytotoxicity and genotoxicity of a trypanocidal drug quinapyraminesulfate loaded-sodium alginate nanoparticles in mammalian cells | en_US |
| dc.title.alternative | Not Available | en_US |
| dc.type | Research Paper | en_US |
| dc.publication.projectcode | Not Available | en_US |
| dc.publication.journalname | International Journal of Biological Macromolecules | en_US |
| dc.publication.volumeno | 88 | en_US |
| dc.publication.pagenumber | 146-155 | en_US |
| dc.publication.divisionUnit | Not Available | en_US |
| dc.publication.sourceUrl | 10.1016/j.ijbiomac.2016.03.034 | en_US |
| dc.publication.authorAffiliation | ICAR::National Research Centre on Equines | en_US |
| dc.ICARdataUseLicence | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf | en_US |
| dc.publication.naasrating | 11.16 | en_US |
| dc.publication.impactfactor | 6.953 | en_US |
| Appears in Collections: | AS-NRCE-Publication | |
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