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http://krishi.icar.gov.in/jspui/handle/123456789/74620| Title: | Cytotoxicity and genotoxicity of a trypanocidal drug quinapyraminesulfate loaded-sodium alginate nanoparticles in mammalian cells |
| Other Titles: | Not Available |
| Authors: | Anju Manuja, Balvinder Kumar, Meenu Chopra, Anshu Bajaj, Rajender Kumara, Neeraj Dilbaghi, Sandeep Kumar, Sandeep Singh, T. Riyesh, Suresh C. Yadav |
| ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
| Author's Affiliated institute: | ICAR::National Research Centre on Equines |
| Published/ Complete Date: | 2016-03-18 |
| Project Code: | Not Available |
| Keywords: | Trypanosoma; Nanomedicine; Genotoxicity; Cytotoxicity; Oxidative stress |
| Publisher: | Elsevier |
| Citation: | Not Available |
| Series/Report no.: | Not Available; |
| Abstract/Description: | We synthesized quinapyramine sulfate loaded-sodium alginate nanoparticles (QS-NPs) to reduce unde-sirable toxic effects of QS against the parasite Trypanosoma evansi, a causative agent of trypanosomosis. To determine the safety of the formulated nanoparticles, biocompatibility of QS-NPs was determined using Vero, Hela cell lines and horse erythrocytes in a dose-dependent manner. Our experiments unveiled a concentration-dependent safety/cytotoxicity (metabolic activity), genotoxicity (DNA damage, chromosomal aberrations), production of reactive oxygen species and hemolysis in QS-NPs treated cells. Annexin-Vpropidium iodide (PI) staining showed no massive apoptosis or necrosis. However, at very high doses(more than 300 times than the effective doses), we observed more toxicity in QS-NPs treated cells as compared to QS treated cells. QS-NPs were safe at effective trypanocidal doses and even at doses several times higher than the effective dose. |
| Description: | Not Available |
| ISSN: | Not Available |
| Type(s) of content: | Research Paper |
| Sponsors: | Not Available |
| Language: | English |
| Name of Journal: | International Journal of Biological Macromolecules |
| NAAS Rating: | 11.16 |
| Impact Factor: | 6.953 |
| Volume No.: | 88 |
| Page Number: | 146-155 |
| Name of the Division/Regional Station: | Not Available |
| Source, DOI or any other URL: | 10.1016/j.ijbiomac.2016.03.034 |
| URI: | http://krishi.icar.gov.in/jspui/handle/123456789/74620 |
| Appears in Collections: | AS-NRCE-Publication |
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