KRISHI
ICAR RESEARCH DATA REPOSITORY FOR KNOWLEDGE MANAGEMENT
(An Institutional Publication and Data Inventory Repository)
"Not Available": Please do not remove the default option "Not Available" for the fields where metadata information is not available
"1001-01-01": Date not available or not applicable for filling metadata infromation
"1001-01-01": Date not available or not applicable for filling metadata infromation
Please use this identifier to cite or link to this item:
http://krishi.icar.gov.in/jspui/handle/123456789/76827
Title: | Nano zinc supplementation affects immunity, hormonal profile, hepatic superoxide dismutase 1 (SOD1) gene expression and vital organ histology in Wistar albino Rats |
Other Titles: | Not Available |
Authors: | Swain PS Rajendran D Rao SBN Gowda NKS Krishnamoorthy P Mondal S Mor Selvaraj S |
ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
Author's Affiliated institute: | ICAR::National Institute of Veterinary Epidemiology and Disease Informatics ICAR-National Institute of Animal Nutrition and Physiology, Bangalore, Dairy Cattle Nutrition Division, ICAR- National Dairy Research Institute, Karnal, Haryana, Fisheries and Animal Resources Development Department, Government of Odisha, Baranga, Cuttack, ICAR-National Institute of Veterinary Epidemiology and Disease Informatics, Bangalore, 560064, India |
Published/ Complete Date: | 2022-07-25 |
Project Code: | Not Available |
Keywords: | Immunity status Nano Zn Organ architecture Rats Superoxide dismutase-1 (SOD1) gene expression |
Publisher: | Springer |
Citation: | Swain, P.S., Rajendran, D., Rao, S.B.N. et al. Nano Zinc Supplementation Affects Immunity, Hormonal Profile, Hepatic Superoxide Dismutase 1 (SOD1) Gene Expression and Vital Organ Histology in Wister Albino Rats. Biol Trace Elem Res 201, 2416–2426 (2023). |
Series/Report no.: | Not Available; |
Abstract/Description: | The study was conducted to assess nano zinc (ZnN) as a feed supplement with an aim to compare the supplemental dose of inorganic zinc (ZnI). ZnN was synthesized from 0.45 molar (M) zinc nitrate [Zn(NO3)2.6H2O] and 0.9 M sodium hydroxide (NaOH) and was confirmed to be of ZnN by TEM-EDAX measurements. Wister albino rats (rats; 84, 53.6 ± 0.65 g) were divided into seven groups (4 replicate with 3 rats each) and given feed supplemented with zinc for 60 days with either of the following diets: (1) normal control (NC): basal diet (BD) + no supplemental Zn; (2) ZnI-25: BD + 25 mg/kg Zn from inorganic ZnO; (3) ZnN-25: BD + 25 mg/kg of ZnN; (4) ZnN-12.5: BD + 12.5 mg/kg of ZnN; (5) ZnN-6.25: BD + 6.25 mg/kg of ZnN; (6) ZnN-3.125: BD + 3.125 mg/kg of ZnN; (7) ZnN-50: BD + 50 mg/kg of ZnN. T3 and insulin-like growth factor-1 (IGF-1) hormone levels were similar among groups (P > 0.05), whereas T4 and testosterone were significantly affected, based on supplemented dose. Zn supplementation improved both cell-mediated and humoral immunity. However, both cell-mediated immunity at 24 h and humoral immunity were statistically similar in ZnI-25 and ZnN-6.25 groups. Superoxide dismutase 1 gene expression was found to be similar in all experimental groups. The vascular degeneration were found in liver tissues moderately in NC, mildly in ZnN-6.25 and ZnN-3.125 groups, and no observable changes were noticed in kidney and spleen tissues. However, there was a mild damage in intestinal epithelium of ZnN-25 group rats, hyperplasia of goblet cells, and moderate damage in intestinal villi were observed in ZnN-50 group rats. From the study, it can be concluded that ZnN at half the dose of ZnI showed similar or better responses in terms of immunity, SOD-1 expression, hormonal profiles, and the tissue architecture of vital organs in rats, i.e., 25 mg/kg of Zn from ZnI and 12.5 mg/kg of ZnN impacted similar biological responses like immunity, SOD-1 expression, hormonal profiles, and the tissue architecture of vital organs in rats. |
Description: | Not Available |
ISSN: | 0163-4984 |
Type(s) of content: | Research Paper |
Sponsors: | Not Available |
Language: | English |
Name of Journal: | Biological Trace Element Research |
Journal Type: | Peer reviewed Journal |
NAAS Rating: | 9.74 |
Impact Factor: | 4.081 |
Volume No.: | 201 |
Page Number: | 2416-2426 |
Name of the Division/Regional Station: | Not Available |
Source, DOI or any other URL: | 10.1007/s12011-022-03355-8 |
URI: | http://krishi.icar.gov.in/jspui/handle/123456789/76827 |
Appears in Collections: | AS-NIVEDI-Publication |
Files in This Item:
There are no files associated with this item.
Items in KRISHI are protected by copyright, with all rights reserved, unless otherwise indicated.