KRISHI
ICAR RESEARCH DATA REPOSITORY FOR KNOWLEDGE MANAGEMENT
(An Institutional Publication and Data Inventory Repository)
"Not Available": Please do not remove the default option "Not Available" for the fields where metadata information is not available
"1001-01-01": Date not available or not applicable for filling metadata infromation
"1001-01-01": Date not available or not applicable for filling metadata infromation
Please use this identifier to cite or link to this item:
http://krishi.icar.gov.in/jspui/handle/123456789/77223
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hajam IA, Dar PA, Chandrasekar S, Nanda RK, Kishore S, Bhanuprakash V, Ganesh K. | en_US |
dc.date.accessioned | 2023-05-12T10:11:06Z | - |
dc.date.available | 2023-05-12T10:11:06Z | - |
dc.date.issued | 2013-12-01 | - |
dc.identifier.issn | Not Available | - |
dc.identifier.uri | http://krishi.icar.gov.in/jspui/handle/123456789/77223 | - |
dc.description.abstract | Foot-and-mouth disease virus (FMDV) is one of the most contagious animal virus known that affects livestock health and production. This study aimed to investigate the effect of flagellin, a toll-like receptor 5 agonist, on the immune responses to inactivated FMDV antigen in guinea pig model. Our results showed that the co-administration of flagellin with FMDV antigen through intradermal route induces earlier and higher anti-FMDV neutralizing antibody responses as compared to FMDV antigen alone. Both IgG1 and IgG2 antibody-isotype responses were enhanced, but the IgG1/IgG2 ratios were relatively low, indicative of TH1 type of immune activation. On live viral challenge, flagellin+FMDV immunized guinea pigs showed 70% (7 out of 10) protection rate as compared to 40% (4 out of 10) in FMDV alone immunized guinea pigs. The results demonstrate that the co-administration of flagellin augments immune responses (preferably TH1 type) and protective efficacy against FMDV in guinea pigs. | en_US |
dc.language.iso | English | en_US |
dc.publisher | Elsevier | en_US |
dc.subject | Flagellin; Foot-and-mouth disease virus; Guinea pig; Immune response; Molecular adjuvant. | en_US |
dc.title | Co-administration of flagellin augments immune responses to inactivated foot-and-mouth disease virus (FMDV) antigen. | en_US |
dc.type | Research Paper | en_US |
dc.publication.journalname | Research In Veterinary Science | en_US |
dc.publication.volumeno | 95(3) | en_US |
dc.publication.pagenumber | 936-941 | en_US |
dc.publication.divisionUnit | ICAR-IVRI Campus, Hebbal, Bengaluru 560024, Karnataka | en_US |
dc.publication.sourceUrl | 10.1016/j.rvsc.2013.07.021 | en_US |
dc.publication.authorAffiliation | ICAR:Indian Veterinary Research Institute | en_US |
dc.ICARdataUseLicence | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf | en_US |
dc.publication.journaltype | Included in NAAS Journal list | en_US |
dc.publication.naasrating | 8.55 | en_US |
dc.publication.impactfactor | 2.554 | en_US |
Appears in Collections: | AS-IVRI-Publication |
Files in This Item:
There are no files associated with this item.
Items in KRISHI are protected by copyright, with all rights reserved, unless otherwise indicated.