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http://krishi.icar.gov.in/jspui/handle/123456789/77223
Title: | Co-administration of flagellin augments immune responses to inactivated foot-and-mouth disease virus (FMDV) antigen. |
Authors: | Hajam IA, Dar PA, Chandrasekar S, Nanda RK, Kishore S, Bhanuprakash V, Ganesh K. |
ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
Author's Affiliated institute: | ICAR:Indian Veterinary Research Institute |
Published/ Complete Date: | 2013-12-01 |
Keywords: | Flagellin; Foot-and-mouth disease virus; Guinea pig; Immune response; Molecular adjuvant. |
Publisher: | Elsevier |
Abstract/Description: | Foot-and-mouth disease virus (FMDV) is one of the most contagious animal virus known that affects livestock health and production. This study aimed to investigate the effect of flagellin, a toll-like receptor 5 agonist, on the immune responses to inactivated FMDV antigen in guinea pig model. Our results showed that the co-administration of flagellin with FMDV antigen through intradermal route induces earlier and higher anti-FMDV neutralizing antibody responses as compared to FMDV antigen alone. Both IgG1 and IgG2 antibody-isotype responses were enhanced, but the IgG1/IgG2 ratios were relatively low, indicative of TH1 type of immune activation. On live viral challenge, flagellin+FMDV immunized guinea pigs showed 70% (7 out of 10) protection rate as compared to 40% (4 out of 10) in FMDV alone immunized guinea pigs. The results demonstrate that the co-administration of flagellin augments immune responses (preferably TH1 type) and protective efficacy against FMDV in guinea pigs. |
ISSN: | Not Available |
Type(s) of content: | Research Paper |
Language: | English |
Name of Journal: | Research In Veterinary Science |
Journal Type: | Included in NAAS Journal list |
NAAS Rating: | 8.55 |
Impact Factor: | 2.554 |
Volume No.: | 95(3) |
Page Number: | 936-941 |
Name of the Division/Regional Station: | ICAR-IVRI Campus, Hebbal, Bengaluru 560024, Karnataka |
Source, DOI or any other URL: | 10.1016/j.rvsc.2013.07.021 |
URI: | http://krishi.icar.gov.in/jspui/handle/123456789/77223 |
Appears in Collections: | AS-IVRI-Publication |
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